Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)
1_MGSED 6_ HGAQN 11_ PSCKI 16_ MTFRP 21_ TMEEF 26_ KDFNK 31_ YVAYI 36_ ESQGA 41_ HRAGL 46_ AKIIP 51_ PKEWK 56_ PRQTY 61_ DDIDD 66_ VVIPA 71_ PIQQV 76_ VTGQS 81_ GLFTQ 86_ YNIQK 91_ KAMTV 96_ GEYRR 101_ LANSE 106_ KYCTP 111_ RHQDF 116_ DDLER 121_ KYWKN 126_ LTFVS 131_ PIYGA 136_ DISGS 141_ LYDDD 146_ VAQWN 151_ IGSLR 156_ TILDM 161_ VEREC 166_ GTIIE 171_ GVNTP 176_ YLYFG 181_ MWKTT 186_ FAWHT 191_ EDMDL 196_ YSINY 201_ LHFGE 206_ PKSWY 211_ AIPPE 216_ HGKRL 221_ ERLAI 226_ GFFPG 231_ SSQGC 236_ DAFLR 241_ HKMTL 246_ ISPII 251_ LKKYG 256_ IPFSR 261_ ITQEA 266_ GEFMI 271_ TFPYG 276_ YHAGF 281_ NHGFN 286_ CAEST 291_ NFATL 296_ RWIDY 301_ GKVAT 306_ QCTCR 311_ KDMVK 316_ ISMDV 321_ FVRIL 326_ QPERY 331_ ELWKQ 336_ GKDLT 341_ VLDHT 346_ RPTAL 351_ TSPEL 356_ SSWSA 361_ SRASL 366_ KAKLL 371_ RRSHR 376_ KRSQP 381_ KKPKP 386_ EDPKF 391_ PGEGT 396_ AGAAL 401_ LEEAG 406_ GSVKE 411_ EAGPE 416_ VDPEE 421_ EEEEP 426_ QPLPH 431_ GREAE 436_ GAEED 441_ GRGKL 446_ RPTKA 451_ KSERK 456_ KKSFG 461_ LLPPQ 466_ LPPPP 471_ AHFPS 476_ EEALW 481_ LPSPL 486_ EPPVL 491_ GPGPA 496_ AMEES 501_ PLPAP 506_ LNVVP 511_ PEVPS 516_ EELEA 521_ KPRPI 526_ IPMLY 531_ VVPRP 536_ GKAAF 541_ NQEHV 546_ SCQQA 551_ FEHFA 556_ QKGPT 561_ WKEPV 566_ SPMEL 571_ TGPED 576_ GAASS 581_ GAGRM 586_ ETKAR 591_ AGEGQ 596_ APSTF 601_ SKLKM 606_ EIKKS 611_ RRHPL 616_ GRPPT 621_ RSPLS 626_ VVKQE 631_ ASSDE 636_ EASPF 641_ SGEED 646_ VSDPD 651_ ALRPL 656_ LSLQW 661_ KNRAA 666_ SFQAE 671_ RKFNA 676_ AAART 681_ EPYCA 686_ ICTLF 691_ YPYCQ 696_ ALQTE 701_ KEAPI 706_ ASLGK 711_ GCPAT 716_ LPSKS 721_ RQKTR 726_ PLIPE 731_ MCFTS 736_ GGENT 741_ EPLPA 746_ NSYIG 751_ DDGTS 756_ PLIAC 761_ GKCCL 766_ QVHAS 771_ CYGIR 776_ PELVN 781_ EGWTC 786_ SRCAA 791_ HAWTA 796_ ECCLC 801_ NLRGG 806_ ALQMT 811_ TDRRW 816_ IHVIC 821_ AIAVP 826_ EARFL 831_ NVIER 836_ HPVDI 841_ SAIPE 846_ QRWKL 851_ KCVYC 856_ RKRMK 861_ KVSGA 866_ CIQCS 871_ YEHCS 876_ TSFHV 881_ TCAHA 886_ AGVLM 891_ EPDDW 896_ PYVVS 901_ ITCLK 906_ HKSGG 911_ HAVQL 916_ LRAVS 921_ LGQVV 926_ ITKNR 931_ NGLYY 936_ RCRVI 941_ GAASQ 946_ TCYEV 951_ NFDDG 956_ SYSDN 961_ LYPES 966_ ITSRD 971_ CVQLG 976_ PPSEG 981_ ELVEL 986_ RWTDG 991_ NLYKA 996_ KFISS 1001_ VTSHI 1006_ YQVEF 1011_ EDGSQ 1016_ LTVKR 1021_ GDIFT 1026_ LEEEL 1031_ PKRVR 1036_ SRLSL 1041_ STGAP 1046_ QEPAF 1051_ SGEEA 1056_ KAAKR 1061_ PRVGT 1066_ PLATE 1071_ DSGRS 1076_ QDYVA 1081_ FVESL 1086_ LQVQG 1091_RPGAP
1: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS)