Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)
1_MSGGA 6_ SATGP 11_ RRGPP 16_ GLEDT 21_ TSKKK 26_ QKDRA 31_ NQESK 36_ DGDPR 41_ KETGS 46_ RYVAQ 51_ AGLEP 56_ LASGD 61_ PSASA 66_ SHAAG 71_ ITGSR 76_ HRTRL 81_ FFPSS 86_ SGSAS 91_ TPQEE 96_ QTKEG 101_ ACEDP 106_ HDLLA 111_ TPTPE 116_ LLLDW 121_ RQSAE 126_ EVIVK 131_ LRVGV 136_ GPLQL 141_ EDVDA 146_ AFTDT 151_ DCVVR 156_ FAGGQ 161_ QWGGV 166_ FYAEI 171_ KSSCA 176_ KVQTR 181_ KGSLL 186_ HLTLP 191_ KKVPM 196_ LTWPS 201_ LLVEA 206_ DEQLC 211_ IPPLN 216_ SQTCL 221_ LGSEE 226_ NLAPL 231_ AGEKA 236_ VPPGN 241_ DPVSP 246_ AMVRS 251_ RNPGK 256_ DDCAK 261_ EEMAV 266_ AADAA 271_ TLVDE 276_ PESMV 281_ NLAFV 286_ KNDSY 291_ EKGPD 296_ SVVVH 301_ VYVKE 306_ ICRDT 311_ SRVLF 316_ REQDF 321_ TLIFQ 326_ TRDGN 331_ FLRLH 336_ PGCGP 341_ HTTFR 346_ WQVKL 351_ RNLIE 356_ PEQCT 361_ FCFTA 366_ SRIDI 371_ CLRKR 376_ QSQRW 381_ GGLEA 386_ PAARV 391_ GGAKV 396_ AVPTG 401_ PTPLD 406_ STPPG 411_ GAPHP 416_ LTGQE 421_ EARAV 426_ EKDKS 431_ KARSE 436_ DTGLD 441_ SVATR 446_ TPMEH 451_ VTPKP 456_ ETHLA 461_ SPKPT 466_ CMVPP 471_ MPHSP 476_ VSGDS 481_ VEEEE 486_ EEEKK 491_ VCLPG 496_ FTGLV 501_ NLGNT 506_ CFMNS 511_ VIQSL 516_ SNTRE 521_ LRDFF 526_ HDRSF 531_ EAEIN 536_ YNNPL 541_ GTGGR 546_ LAIGF 551_ AVLLR 556_ ALWKG 561_ THHAF 566_ QPSKL 571_ KAIVA 576_ SKASQ 581_ FTGYA 586_ QHDAQ 591_ EFMAF 596_ LLDGL 601_ HEDLN 606_ RIQNK 611_ PYTET 616_ VDSDG 621_ RPDEV 626_ VAEEA 631_ WQRHK 636_ MRNDS 641_ FIVDL 646_ FQGQY 651_ KSKLV 656_ CPVCA 661_ KVSIT 666_ FDPFL 671_ YLPVP 676_ LPQKQ 681_ KVLPV 686_ FYFAR 691_ EPHSK 696_ PIKFL 701_ VSVSK 706_ ENSTA 711_ SEVLD 716_ SLSQS 721_ VHVKP 726_ ENLRL 731_ AEVIK 736_ NRFHR 741_ VFLPS 746_ HSLDT 751_ VSPSD 756_ TLLCF 761_ ELLSS 766_ ELAKE 771_ RVVVL 776_ EVQQR 781_ PQVPS 786_ VPISK 791_ CAACQ 796_ RKQQS 801_ EDEKL 806_ KRCTR 811_ CYRVG 816_ YCNQL 821_ CQKTH 826_ WPDHK 831_ GLCRP 836_ ENIGY 841_ PFLVS 846_ VPASR 851_ LTYAR 856_ LAQLL 861_ EGYAR 866_ YSVSV 871_ FQPPF 876_ QPGRM 881_ ALESQ 886_ SPGCT 891_ TLLST 896_ GSLEA 901_ GDSER 906_ DPIQP 911_ PELQL 916_ VTPMA 921_ EGDTG 926_ LPRVW 931_ AAPDR 936_ GPVPS 941_ TSGIS 946_ SEMLA 951_ SGPIE 956_ VGSLP 961_ AGERV 966_ SRPEA 971_ AVPGY 976_ QHPSE 981_ AMNAH 986_ TPQFF 991_ IYKID 996_ SSNRE 1001_ QRLED 1006_ KGDTP 1011_ LELGD 1016_ DCSLA 1021_ LVWRN 1026_ NERLQ 1031_ EFVLV 1036_ ASKEL 1041_ ECAED 1046_ PGSAG 1051_ EAARA 1056_ GHFTL 1061_ DQCLN 1066_ LFTRP 1071_ EVLAP 1076_ EEAWY 1081_ CPQCK 1086_ QHREA 1091_ SKQLL 1096_ LWRLP 1101_ NVLIV 1106_ QLKRF 1111_ SFRSF 1116_ IWRDK 1121_ INDLV 1126_ EFPVR 1131_ NLDLS 1136_ KFCIG 1141_ QKEEQ 1146_ LPSYD 1151_ LYAVI 1156_ NHYGG 1161_ MIGGH 1166_ YTACA 1171_ RLPND 1176_ RSSQR 1181_ SDVGW 1186_ RLFDD 1191_ STVTT 1196_ VDESQ 1201_ VVTRY 1206_ AYVLF 1211_ YRRRN 1216_ SPVER 1221_ PPRAG 1226_ HSEHH 1231_ PDLGP 1236_ AAEAA 1241_ ASQAS 1246_ RIWQE 1251_ LEAEE 1256_ EPVPE 1261_ GSGPL 1266_ GPWGP 1271_ QDWVG 1276_ PLPRG 1281_ PTTPD 1286_ EGCLR 1291_ YFVLG 1296_ TVAAL 1301_ VALVL 1306_ NVFYP 1311_LVSQS
1: Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:19465887, PubMed:24356957). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:24356957). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (PubMed:21849505). Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1 (PubMed:22128162, PubMed:33978709). Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (PubMed:38943386). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (PubMed:33094816)