E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
1_MDEQS 6_ VESIA 11_ EVFRC 16_ FICME 21_ KLRDA 26_ RLCPH 31_ CSKLC 36_ CFSCI 41_ RRWLT 46_ EQRAQ 51_ CPHCR 56_ APLQL 61_ RELVN 66_ CRWAE 71_ EVTQQ 76_ LDTLQ 81_ LCSLT 86_ KHEEN 91_ EKDKC 96_ ENHHE 101_ KLSVF 106_ CWTCK 111_ KCICH 116_ QCALW 121_ GGMHG 126_ GHTFK 131_ PLAEI 136_ YEQHV 141_ TKVNE 146_ EVAKL 151_ RRRLM 156_ ELISL 161_ VQEVE 166_ RNVEA 171_ VRNAK 176_ DERVR 181_ EIRNA 186_ VEMMI 191_ ARLDT 196_ QLKNK 201_ LITLM 206_ GQKTS 211_ LTQET 216_ ELLES 221_ LLQEV 226_ EHQLR 231_ SCSKS 236_ ELISK 241_ SSEIL 246_ MMFQQ 251_ VHRKP 256_ MASFV 261_ TTPVP 266_ PDFTS 271_ ELVPS 276_ YDSAT 281_ FVLEN 286_ FSTLR 291_ QRADP 296_ VYSPP 301_ LQVSG 306_ LCWRL 311_ KVYPD 316_ GNGVV 321_ RGYYL 326_ SVFLE 331_ LSAGL 336_ PETSK 341_ YEYRV 346_ EMVHQ 351_ SCNDP 356_ TKNII 361_ REFAS 366_ DFEVG 371_ ECWGY 376_ NRFFR 381_ LDLLA 386_ NEGYL 391_ NPQND 396_ TVILR 401_ FQVRS 406_ PTFFQ 411_ KSRDQ 416_ HWYIT 421_ QLEAA 426_ QTSYI 431_ QQINN 436_ LKERL 441_ TIELS 446_ RTQKS 451_ RDLSP 456_ PDNHL 461_ SPQND 466_ DALET 471_ RAKKS 476_ ACSDM 481_ LLEGG 486_ PTTAS 491_ VREAK 496_ EDEED 501_ EEKIQ 506_ NEDYH 511_ HELSD 516_ GDLDL 521_ DLVYE 526_ DEVNQ 531_ LDGSS 536_ SSASS 541_ TATSN 546_ TEEND 551_ IDEET 556_ MSGEN 561_ DVEYN 566_ NMELE 571_ EGELM 576_ EDAAA 581_ AGPAG 586_ SSHGY 591_ VGSSS 596_ RISRR 601_ THLCS 606_ AATSS 611_ LLDID 616_ PLILI 621_ HLLDL 626_ KDRSS 631_ IENLW 636_ GLQPR 641_ PPASL 646_ LQPTA 651_ SYSRK 656_ DKDQR 661_ KQQAM 666_ WRVPS 671_ DLKML 676_ KRLKT 681_ QMAEV 686_ RCMKT 691_ DVKNT 696_ LSEIK 701_ SSSAA 706_ SGDMQ 711_ TSLFS 716_ ADQAA 721_ LAACG 726_ TENSG 731_ RLQDL 736_ GMELL 741_ AKSSV 746_ ANCYI 751_ RNSTN 756_ KKSNS 761_ PKPAR 766_ SSVAG 771_ SLSLR 776_ RAVDP 781_ GENSR 786_ SKGDC 791_ QTLSE 796_ GSPGS 801_ SQSGS 806_ RHSSP 811_ RALIH 816_ GSIGD 821_ ILPKT 826_ EDRQC 831_ KALDS 836_ DAVVV 841_ AVFSG 846_ LPAVE 851_ KRRKM 856_ VTLGA 861_ NAKGG 866_ HLEGL 871_ QMTDL 876_ ENNSE 881_ TGELQ 886_ PVLPE 891_ GASAA 896_ PEEGM 901_ SSDSD 906_ IECDT 911_ ENEEQ 916_ EEHTS 921_ VGGFH 926_ DSFMV 931_ MTQPP 936_ DEDTH 941_ SSFPD 946_ GEQIG 951_ PEDLS 956_FNTDE
1: E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724)