Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]
1_MLRRP 6_ APALA 11_ PAARL 16_ LLAGL 21_ LCGGG 26_ VWAAR 31_ VNKHK 36_ PWLEP 41_ TYHGI 46_ VTEND 51_ NTVLL 56_ DPPLI 61_ ALDKD 66_ APLRF 71_ AESFE 76_ VTVTK 81_ EGEIC 86_ GFKIH 91_ GQNVP 96_ FDAVV 101_ VDKST 106_ GEGVI 111_ RSKEK 116_ LDCEL 121_ QKDYS 126_ FTIQA 131_ YDCGK 136_ GPDGT 141_ NVKKS 146_ HKATV 151_ HIQVN 156_ DVNEY 161_ APVFK 166_ EKSYK 171_ ATVIE 176_ GKQYD 181_ SILRV 186_ EAVDA 191_ DCSPQ 196_ FSQIC 201_ SYEII 206_ TPDVP 211_ FTVDK 216_ DGYIK 221_ NTEKL 226_ NYGKE 231_ HQYKL 236_ TVTAY 241_ DCGKK 246_ RATED 251_ VLVKI 256_ SIKPT 261_ CTPGW 266_ QGWNN 271_ RIEYE 276_ PGTGA 281_ LAVFP 286_ NIHLE 291_ TCDEP 296_ VASVQ 301_ ATVEL 306_ ETSHI 311_ GKGCD 316_ RDTYS 321_ EKSLH 326_ RLCGA 331_ AAGTA 336_ ELLPS 341_ PSGSL 346_ NWTMG 351_ LPTDN 356_ GHDSD 361_ QVFEF 366_ NGTQA 371_ VRIPD 376_ GVVSV 381_ SPKEP 386_ FTISV 391_ WMRHG 396_ PFGRK 401_ KETIL 406_ CSSDK 411_ TDMNR 416_ HHYSL 421_ YVHGC 426_ RLIFL 431_ FRQDP 436_ SEEKK 441_ YRPAE 446_ FHWKL 451_ NQVCD 456_ EEWHH 461_ YVLNV 466_ EFPSV 471_ TLYVD 476_ GTSHE 481_ PFSVT 486_ EDYPL 491_ HPSKI 496_ ETQLV 501_ VGACW 506_ QEFSG 511_ VENDN 516_ ETEPV 521_ TVASA 526_ GGDLH 531_ MTQFF 536_ RGNLA 541_ GLTLR 546_ SGKLA 551_ DKKVI 556_ DCLYT 561_ CKEGL 566_ DLQVL 571_ EDSGR 576_ GVQIQ 581_ AHPSQ 586_ LVLTL 591_ EGEDL 596_ GELDK 601_ AMQHI 606_ SYLNS 611_ RQFPT 616_ PGIRR 621_ LKITS 626_ TIKCF 631_ NEATC 636_ ISVPP 641_ VDGYV 646_ MVLQP 651_ EEPKI 656_ SLSGV 661_ HHFAR 666_ AASEF 671_ ESSEG 676_ VFLFP 681_ ELRII 686_ STITR 691_ EVEPE 696_ GDGAE 701_ DPTVQ 706_ ESLVS 711_ EEIVH 716_ DLDTC 721_ EVTVE 726_ GEELN 731_ HEQES 736_ LEVDM 741_ ARLQQ 746_ KGIEV 751_ SSSEL 756_ GMTFT 761_ GVDTM 766_ ASYEE 771_ VLHLL 776_ RYRNW 781_ HARSL 786_ LDRKF 791_ KLICS 796_ ELNGR 801_ YISNE 806_ FKVEV 811_ NVIHT 816_ ANPME 821_ HANHM 826_ AAQPQ 831_ FVHPE 836_ HRSFV 841_ DLSGH 846_ NLANP 851_ HPFAV 856_ VPSTA 861_ TVVIV 866_ VCVSF 871_ LVFMI 876_ ILGVF 881_ RIRAA 886_ HRRTM 891_ RDQDT 896_ GKENE 901_ MDWDD 906_ SALTI 911_ TVNPM 916_ ETYED 921_ QHSSE 926_ EEEEE 931_ EEEEE 936_ SEDGE 941_ EEDDI 946_ TSAES 951_ ESSEE 956_ EEGEQ 961_ GDPQN 966_ ATRQQ 971_ QLEWD 976_DSTLS
1: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431)
2: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding (PubMed:15037614)
3: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP (PubMed:15037614)