Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)
1_MSAQS 6_ LPAAT 11_ PPTQK 16_ PPRII 21_ RPRPP 26_ SRSRA 31_ AQSPG 36_ PPHNG 41_ SSPQE 46_ LPRNS 51_ NDAPT 56_ PMCTP 61_ IFWEP 66_ PAASL 71_ KPPAL 76_ LPPSA 81_ SRASL 86_ DSQTS 91_ PDSPS 96_ STPTP 101_ SPVSR 106_ RSASP 111_ EPAPR 116_ SPVPP 121_ PKPSG 126_ SPCTP 131_ LLPMA 136_ GVLAQ 141_ NGSAS 146_ APGTV 151_ RRLAG 156_ RFEGG 161_ AEGRA 166_ QDADA 171_ PEPGL 176_ QARAD 181_ VNGER 186_ EAPLT 191_ GSGSQ 196_ ENGAP 201_ DAGLA 206_ CPPCC 211_ PCVCH 216_ TTRPG 221_ LELRW 226_ VPVGG 231_ YEEVP 236_ RVPRR 241_ ASPLR 246_ TSRSR 251_ PHPPS 256_ IGHPA 261_ VVLTS 266_ YRSTA 271_ ERKLL 276_ PLLKP 281_ PKPTR 286_ VRQDA 291_ TIFGD 296_ PPQPD 301_ LDLLS 306_ EDGIQ 311_ TGDSP 316_ DEAPQ 321_ NTPPA 326_ TVEGR 331_ EEEGL 336_ EVLKE 341_ QNWEL 346_ PLQDE 351_ PLYQT 356_ YRAAV 361_ LSEEL 366_ WGVGE 371_ DGSPS 376_ PANAG 381_ DAPTF 386_ PRPPG 391_ PRNTL 396_ WQELP 401_ AVQAS 406_ GLLDT 411_ LSPQE 416_ RRMQE 421_ SLFEV 426_ VTSEA 431_ SYLRS 436_ LRLLT 441_ DTFVL 446_ SQALR 451_ DTLTP 456_ RDHHT 461_ LFSNV 466_ QRVQG 471_ VSERF 476_ LATLL 481_ SRVRS 486_ SPHIS 491_ DLCDV 496_ VHAHA 501_ VGPFS 506_ VYVDY 511_ VRNQQ 516_ YQEET 521_ YSRLM 526_ DTNVR 531_ FSAEL 536_ RRLQS 541_ LPKCE 546_ RLPLP 551_ SFLLL 556_ PFQRI 561_ TRLRM 566_ LLQNI 571_ LRQTE 576_ EGSSR 581_ QENAQ 586_ KALGA 591_ VSKII 596_ ERCSA 601_ EVGRM 606_ KQTEE 611_ LIRLT 616_ QRLRF 621_ HKVKA 626_ LPLVS 631_ WSRRL 636_ EFQGE 641_ LTELG 646_ CRRGG 651_ VLFAS 656_ RPRFT 661_ PLCLL 666_ LFSDL 671_ LLITQ 676_ PKSGQ 681_ RLQVL 686_ DYAHR 691_ SLVQA 696_ QQVPD 701_ PSGPP 706_ TFRLS 711_ LLSNH 716_ QGRPT 721_ HRLLQ 726_ ASSLS 731_ DMQRW 736_ LGAFP 741_ TPGPL 746_ PCSPD 751_ TIYED 756_ CDCSQ 761_ ELCSE 766_ SSAPA 771_ KTEGR 776_ SLESR 781_ AAPKH 786_ LHKTP 791_ EGWLK 796_ GLPGA 801_ FPAQL 806_ VCEVT 811_ GEHER 816_ RRHLR 821_ QNQRL 826_ LEAVG 831_ SSSGT 836_PNAPP
1: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2