Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1)
1_MAEPF 6_ LSEYQ 11_ HQPQT 16_ SNCTG 21_ AAAVQ 26_ EELNP 31_ ERPPG 36_ AEERV 41_ PEEDS 46_ RWQSR 51_ AFPQL 56_ GGRPG 61_ PEGEG 66_ SLESQ 71_ PPPLQ 76_ TQACP 81_ ESSCL 86_ REGEK 91_ GQNGD 96_ DSSAG 101_ GDFPP 106_ PAEVE 111_ PTPEA 116_ ELLAQ 121_ PCHDS 126_ EASKL 131_ GAPAA 136_ GGEEE 141_ WGQQQ 146_ RQLGK 151_ KKHRR 156_ RPSKK 161_ KRHWK 166_ PYYKL 171_ TWEEK 176_ KKFDE 181_ KQSLR 186_ ASRIR 191_ AEMFA 196_ KGQPV 201_ APYNT 206_ TQFLM 211_ DDHDQ 216_ EEPDL 221_ KTGLY 226_ SKRAA 231_ AKSDD 236_ TSDDD 241_ FMEEG 246_ GEEDG 251_ GSDGM 256_ GGDGS 261_ EFLQR 266_ DFSET 271_ YERYH 276_ TESLQ 281_ NMSKQ 286_ ELIKE 291_ YLELE 296_ KCLSR 301_ MEDEN 306_ NRLRL 311_ ESKRL 316_ GGDDA 321_ RVREL 326_ ELELD 331_ RLRAE 336_ NLQLL 341_ TENEL 346_ HRQQE 351_RAPLS
1: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728)