Transcription factor SOX-30
1_MERAR 6_ PEPPP 11_ QPRPL 16_ RPAPP 21_ PLPVE 26_ GTSFW 31_ AAAME 36_ PPPSS 41_ PTLSA 46_ AASAT 51_ LASSC 56_ GEAVA 61_ SGLQP 66_ AVRRL 71_ LQVKP 76_ EQVLL 81_ LPQPQ 86_ AQNEE 91_ AAASS 96_ AQARL 101_ LQFRP 106_ DLRLL 111_ QPPTA 116_ SDGAT 121_ SRPEL 126_ HPVQP 131_ LALHV 136_ KAKKQ 141_ KLGPS 146_ LDQSV 151_ GPRGA 156_ VETGP 161_ RASRV 166_ VKLEG 171_ PGPAL 176_ GYFRG 181_ DEKGK 186_ LEAEE 191_ VMRDS 196_ MQGGA 201_ GKSPA 206_ AIREG 211_ VIKTE 216_ EPERL 221_ LEDCR 226_ LGAEP 231_ ASNGL 236_ VHGSA 241_ EVILA 246_ PTSGA 251_ FGPHQ 256_ QDLRI 261_ PLTLH 266_ TVPPG 271_ ARIQF 276_ QGAPP 281_ SELIR 286_ LTKVP 291_ LTPVP 296_ TKMQS 301_ LLEPS 306_ VKIET 311_ KDVPL 316_ TVLPS 321_ DAGIP 326_ DTPFS 331_ KDRNG 336_ HVKRP 341_ MNAFM 346_ VWARI 351_ HRPAL 356_ AKANP 361_ AANNA 366_ EISVQ 371_ LGLEW 376_ NKLSE 381_ EQKKP 386_ YYDEA 391_ QKIKE 396_ KHREE 401_ FPGWV 406_ YQPRP 411_ GKRKR 416_ FPLSV 421_ SNVFS 426_ GTTQN 431_ IISTN 436_ PTTVY 441_ PYRSP 446_ TYSVV 451_ IPSLQ 456_ NPITH 461_ PVGET 466_ SPAIQ 471_ LPTPA 476_ VQSPS 481_ PVTLF 486_ QPSVS 491_ SAAQV 496_ AVQDP 501_ SLPVY 506_ PALPP 511_ QRFTG 516_ PSQTD 521_ THQLH 526_ SEATH 531_ TVKQP 536_ TPVSL 541_ ESANR 546_ ISSSA 551_ STAHA 556_ RFATS 561_ TIQPP 566_ REYSS 571_ VSPCP 576_ RSAPI 581_ PQASP 586_ IPHPH 591_ VYQPP 596_ PLGHP 601_ ATLFG 606_ TPPRF 611_ SFHHP 616_ YFLPG 621_ PHYFP 626_ SSTCP 631_ YSRPP 636_ FGYGN 641_ FPSSM 646_ PECLS 651_ YYEDR 656_ YPKHE 661_ GIFST 666_ LNRDY 671_ SFRDY 676_ SSECT 681_ HSENS 686_ RSCEN 691_ MNGTS 696_ YYNSH 701_ SHSGE 706_ ENLNP 711_ VPQLD 716_ IGTLE 721_ NVFTA 726_ PTSTP 731_ SSIQQ 736_ VNVTD 741_ SDEEE 746_EEKVL
1: Acts both as a transcriptional activator and a repressor (PubMed:10359848, PubMed:29739711). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711)