Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)
1_MEELT 6_ IWEQH 11_ TATLS 16_ KDPRR 21_ GFGIA 26_ ISGGR 31_ DRPGG 36_ SMVVS 41_ DVVPG 46_ GPAEG 51_ RLQTG 56_ DHIVM 61_ VNGVS 66_ MENAT 71_ SAFAI 76_ QILKT 81_ CTKMA 86_ NITVK 91_ RPRRI 96_ HLPAT 101_ KASPS 106_ SPGRQ 111_ DSDED 116_ DGPQR 121_ VEEVD 126_ QGRGY 131_ DGDSS 136_ SGSGR 141_ SWDER 146_ SRRPR 151_ PGRRG 156_ RAGSH 161_ GRRSP 166_ GGGSE 171_ ANGLA 176_ LVSGF 181_ KRLPR 186_ QDVQM 191_ KPVKS 196_ VLVKR 201_ RDSEE 206_ FGVKL 211_ GSQIF 216_ IKHIT 221_ DSGLA 226_ ARHRG 231_ LQEGD 236_ LILQI 241_ NGVSS 246_ QNLSL 251_ NDTRR 256_ LIEKS 261_ EGKLS 266_ LLVLR 271_ DRGQF 276_ LVNIP 281_ PAVSD 286_ SDSSP 291_ LEDIS 296_ DLASE 301_ LSQAP 306_ PSHIP 311_ PPPRH 316_ AQRSP 321_ EASQT 326_ DSPVE 331_ SPRLR 336_ RESSV 341_ DSRTI 346_ SEPDE 351_ QRSEL 356_ PRESS 361_ YDIYR 366_ VPSSQ 371_ SMEDR 376_ GYSPD 381_ TRVVR 386_ FLKGK 391_ SIGLR 396_ LAGGN 401_ DVGIF 406_ VSGVQ 411_ AGSPA 416_ DGQGI 421_ QEGDQ 426_ ILQVN 431_ DVPFQ 436_ NLTRE 441_ EAVQF 446_ LLGLP 451_ PGEEM 456_ ELVTQ 461_ RKQDI 466_ FWKMV 471_ QSRVG 476_ DSFYI 481_ RTHFE 486_ LEPSP 491_ PSGLG 496_ FTRGD 501_ VFHVL 506_ DTLHP 511_ GPGQS 516_ HARGG 521_ HWLAV 526_ RMGRD 531_ LREQE 536_ RGIIP 541_ NQSRA 546_ EQLAS 551_ LEAAQ 556_ RAVGV 561_ GPGSS 566_ AGSNA 571_ RAEFW 576_ RLRGL 581_ RRGAK 586_ KTTQR 591_ SREDL 596_ SALTR 601_ QGRYP 606_ PYERV 611_ VLREA 616_ SFKRP 621_ VVILG 626_ PVADI 631_ AMQKL 636_ TAEMP 641_ DQFEI 646_ AETVS 651_ RTDSP 656_ SKIIK 661_ LDTVR 666_ VIAEK 671_ DKHAL 676_ LDVTP 681_ SAIER 686_ LNYVQ 691_ YYPIV 696_ VFFIP 701_ ESRPA 706_ LKALR 711_ QWLAP 716_ ASRRS 721_ TRRLY 726_ AQAQK 731_ LRKHS 736_ SHLFT 741_ ATIPL 746_ NGTSD 751_ TWYQE 756_ LKAII 761_ REQQT 766_ RPIWT 771_ AEDQL 776_ DGSLE 781_ DNLDL 786_ PHHGL 791_ ADSSA 796_ DLSCD 801_ SRVNS 806_ DYETD 811_ GEGGA 816_ YTDGE 821_ GYTDG 826_ EGGPY 831_ TDVDD 836_ EPPAP 841_ ALARS 846_ SEPVQ 851_ ADESQ 856_ SPRDR 861_ GRISA 866_ HQGAQ 871_ VDSRH 876_ PQGQW 881_ RQDSM 886_ RTYER 891_ EALKK 896_ KFMRV 901_ HDAES 906_ SDEDG 911_YDWGP
1: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity)