Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT)
1_MKGGF 6_ TGGDE 11_ YQKHF 16_ LPRDY 21_ LATYY 26_ SFDGS 31_ PSPEA 36_ EMLKF 41_ NLECL 46_ HKTFG 51_ PGGLQ 56_ GDTLI 61_ DIGSG 66_ PTIYQ 71_ VLAAC 76_ DSFQD 81_ ITLSD 86_ FTDRN 91_ REELE 96_ KWLKK 101_ EPGAY 106_ DWTPA 111_ VKFAC 116_ ELEGN 121_ SGRWE 126_ EKEEK 131_ LRAAV 136_ KRVLK 141_ CDVHL 146_ GNPLA 151_ PAVLP 156_ LADCV 161_ LTLLA 166_ MECAC 171_ CSLDA 176_ YRAAL 181_ CNLAS 186_ LLKPG 191_ GHLVT 196_ TVTLR 201_ LPSYM 206_ VGKRE 211_ FSCVA 216_ LEKEE 221_ VEQAV 226_ LDAGF 231_ DIEQL 236_ LHSPQ 241_ SYSVT 246_ NAANN 251_ GVCFI 256_VARKK
1: Functions as a thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds