E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
1_MTSIH 6_ FVVHP 11_ LPGTE 16_ DQLND 21_ RLREV 26_ SEKLN 31_ KYNLN 36_ SHPPL 41_ NVLEQ 46_ ATIKQ 51_ CVVGP 56_ NHAAF 61_ LLEDG 66_ RVCRI 71_ GFSVQ 76_ PDRLE 81_ LGKPD 86_ NNDGS 91_ KLNSN 96_ SGAGR 101_ TSRPG 106_ RTSDS 111_ PWFLS 116_ GSETL 121_ GRLAG 126_ NTLGS 131_ RWSSG 136_ VGGSG 141_ GGSSG 146_ RSSAG 151_ ARDSR 156_ RQTRV 161_ IRTGR 166_ DRGSG 171_ LLGSQ 176_ PQPVI 181_ PASVI 186_ PEELI 191_ SQAQV 196_ VLQGK 201_ SRSVI 206_ IRELQ 211_ RTNLD 216_ VNLAV 221_ NNLLS 226_ RDDED 231_ GDDGD 236_ DTASE 241_ SYLPG 246_ EDLMS 251_ LLDAD 256_ IHSAH 261_ PSVII 266_ DADAM 271_ FSEDI 276_ SYFGY 281_ PSFRR 286_ SSLSR 291_ LGSSR 296_ VLLLP 301_ LERDS 306_ ELLRE 311_ RESVL 316_ RLRER 321_ RWLDG 326_ ASFDN 331_ ERGST 336_ SKEGE 341_ PNLDK 346_ KNTPV 351_ QSPVS 356_ LGEDL 361_ QWWPD 366_ KDGTK 371_ FICIG 376_ ALYSE 381_ LLAVS 386_ SKGEL 391_ YQWKW 396_ SESEP 401_ YRNAQ 406_ NPSLH 411_ HPRAT 416_ FLGLT 421_ NEKIV 426_ LLSAN 431_ SIRAT 436_ VATEN 441_ NKVAT 446_ WVDET 451_ LSSVA 456_ SKLEH 461_ TAQTY 466_ SELQG 471_ ERIVS 476_ LHCCA 481_ LYTCA 486_ QLENS 491_ LYWWG 496_ VVPFS 501_ QRKKM 506_ LEKAR 511_ AKNKK 516_ PKSSA 521_ GISSM 526_ PNITV 531_ GTQVC 536_ LRNNP 541_ LYHAG 546_ AVAFS 551_ ISAGI 556_ PKVGV 561_ LMESV 566_ WNMND 571_ SCRFQ 576_ LRSPE 581_ SLKNM 586_ EKASK 591_ TTEAK 596_ PESKQ 601_ EPVKT 606_ EMGPP 611_ PSPAS 616_ TCSDA 621_ SSIAS 626_ SASMP 631_ YKRRR 636_ STPAP 641_ KEEEK 646_ VNEEQ 651_ WSLRE 656_ VVFVE 661_ DVKNV 666_ PVGKV 671_ LKVDG 676_ AYVAV 681_ KFPGT 686_ SSNTN 691_ CQNSS 696_ GPDAD 701_ PSSLL 706_ QDCRL 711_ LRIDE 716_ LQVVK 721_ TGGTP 726_ KVPDC 731_ FQRTP 736_ KKLCI 741_ PEKTE 746_ ILAVN 751_ VDSKG 756_ VHAVL 761_ KTGNW 766_ VRYCI 771_ FDLAT 776_ GKAEQ 781_ ENNFP 786_ TSSIA 791_ FLGQN 796_ ERNVA 801_ IFTAG 806_ QESPI 811_ ILRDG 816_ NGTIY 821_ PMAKD 826_ CMGGI 831_ RDPDW 836_ LDLPP 841_ ISSLG 846_ MGVHS 851_ LINLP 856_ ANSTI 861_ KKKAA 866_ VIIMA 871_ VEKQT 876_ LMQHI 881_ LRCDY 886_ EACRQ 891_ YLMNL 896_ EQAVV 901_ LEQNL 906_ QMLQT 911_ FISHR 916_ CDGNR 921_ NILHA 926_ CVSVC 931_ FPTSN 936_ KETKE 941_ EEEAE 946_ RSERN 951_ TFAER 956_ LSAVE 961_ AIANA 966_ ISVVS 971_ SNGPG 976_ NRAGS 981_ SSSRS 986_ LRLRE 991_ MMRRS 996_ LRAAG 1001_ LGRHE 1006_ AGASS 1011_ SDHQD 1016_ PVSPP 1021_ IAPPS 1026_ WVPDP 1031_ PAMDP 1036_ DGDID 1041_ FILAP 1046_ AVGSL 1051_ TTAAT 1056_ GTGQG 1061_ PSTST 1066_ IPGPS 1071_ TEPSV 1076_ VESKD 1081_ RKANA 1086_ HFILK 1091_ LLCDS 1096_ VVLQP 1101_ YLREL 1106_ LSAKD 1111_ ARGMT 1116_ PFMSA 1121_ VSGRA 1126_ YPAAI 1131_ TILET 1136_ AQKIA 1141_ KAEIS 1146_ SSEKE 1151_ EDVFM 1156_ GMVCP 1161_ SGTNP 1166_ DDSPL 1171_ YVLCC 1176_ NDTCS 1181_ FTWTG 1186_ AEHIN 1191_ QDIFE 1196_ CRTCG 1201_ LLESL 1206_ CCCTE 1211_ CARVC 1216_ HKGHD 1221_ CKLKR 1226_ TSPTA 1231_ YCDCW 1236_ EKCKC 1241_ KTLIA 1246_ GQKSA 1251_ RLDLL 1256_ YRLLT 1261_ ATNLV 1266_ TLPNS 1271_ RGEHL 1276_ LLFLV 1281_ QTVAR 1286_ QTVEH 1291_ CQYRP 1296_ PRIRE 1301_ DRNRK 1306_ TASPE 1311_ DSDMP 1316_ DHDLE 1321_ PPRFA 1326_ QLALE 1331_ RVLQD 1336_ WNALK 1341_ SMIMF 1346_ GSQEN 1351_ KDPLS 1356_ ASSRI 1361_ GHLLP 1366_ EEQVY 1371_ LNQQS 1376_ GTIRL 1381_ DCFTH 1386_ CLIVK 1391_ CTADI 1396_ LLLDT 1401_ LLGTL 1406_ VKELQ 1411_ NKYTP 1416_ GRREE 1421_ AIAVT 1426_ MRFLR 1431_ SVARV 1436_ FVILS 1441_ VEMAS 1446_ SKKKN 1451_ NFIPQ 1456_ PIGKC 1461_ KRVFQ 1466_ ALLPY 1471_ AVEEL 1476_ CNVAE 1481_ SLIVP 1486_ VRMGI 1491_ ARPTA 1496_ PFTLA 1501_ STSID 1506_ AMQGS 1511_ EELFS 1516_ VEPLP 1521_ PRPSS 1526_ DQSSS 1531_ SSQSQ 1536_ SSYII 1541_ RNPQQ 1546_ RRISQ 1551_ SQPVR 1556_ GRDEE 1561_ QDDIV 1566_ SADVE 1571_ EVEVV 1576_ EGVAG 1581_ EEDHH 1586_ DEQEE 1591_ HGEEN 1596_ AEAEG 1601_ QHDEH 1606_ DEDGS 1611_ DMELD 1616_ LLAAA 1621_ ETESD 1626_ SESNH 1631_ SNQDN 1636_ ASGRR 1641_ SVVTA 1646_ ATAGS 1651_ EAGAS 1656_ SVPAF 1661_ FSEDD 1666_ SQSND 1671_ SSDSD 1676_ SSSSQ 1681_ SDDIE 1686_ QETFM 1691_ LDEPL 1696_ ERTTN 1701_ SSHAN 1706_ GAAQA 1711_ PRSMQ 1716_ WAVRN 1721_ TQHQR 1726_ AASTA 1731_ PSSTS 1736_ TPAAS 1741_ SAGLI 1746_ YIDPS 1751_ NLRRS 1756_ GTIST 1761_ SAAAA 1766_ AAALE 1771_ ASNAS 1776_ SYLTS 1781_ ASSLA 1786_ RAYSI 1791_ VIRQI 1796_ SDLMG 1801_ LIPKY 1806_ NHLVY 1811_ SQIPA 1816_ AVKLT 1821_ YQDAV 1826_ NLQNY 1831_ VEEKL 1836_ IPTWN 1841_ WMVSI 1846_ MDSTE 1851_ AQLRY 1856_ GSALA 1861_ SAGDP 1866_ GHPNH 1871_ PLHAS 1876_ QNSAR 1881_ RERMT 1886_ AREEA 1891_ SLRTL 1896_ EGRRR 1901_ ATLLS 1906_ ARQGM 1911_ MSARG 1916_ DFLNY 1921_ ALSLM 1926_ RSHND 1931_ EHSDV 1936_ LPVLD 1941_ VCSLK 1946_ HVAYV 1951_ FQALI 1956_ YWIKA 1961_ MNQQT 1966_ TLDTP 1971_ QLERK 1976_ RTREL 1981_ LELGI 1986_ DNEDS 1991_ EHEND 1996_ DDTNQ 2001_ SATLN 2006_ DKDDD 2011_ SLPAE 2016_ TGQNH 2021_ PFFRR 2026_ SDSMT 2031_ FLGCI 2036_ PPNPF 2041_ EVPLA 2046_ EAIPL 2051_ ADQPH 2056_ LLQPN 2061_ ARKED 2066_ LFGRP 2071_ SQGLY 2076_ SSSAS 2081_ SGKCL 2086_ MEVTV 2091_ DRNCL 2096_ EVLPT 2101_ KMSYA 2106_ ANLKN 2111_ VMNMQ 2116_ NRQKK 2121_ EGEEQ 2126_ PVLPE 2131_ ETESS 2136_ KPGPS 2141_ AHDLA 2146_ AQLKS 2151_ SLLAE 2156_ IGLTE 2161_ SEGPP 2166_ LTSFR 2171_ PQCSF 2176_ MGMVI 2181_ SHDML 2186_ LGRWR 2191_ LSLEL 2196_ FGRVF 2201_ MEDVG 2206_ AEPGS 2211_ ILTEL 2216_ GGFEV 2221_ KESKF 2226_ RREME 2231_ KLRNQ 2236_ QSRDL 2241_ SLEVD 2246_ RDRDL 2251_ LIQQT 2256_ MRQLN 2261_ NHFGR 2266_ RCATT 2271_ PMAVH 2276_ RVKVT 2281_ FKDEP 2286_ GEGSG 2291_ VARSF 2296_ YTAIA 2301_ QAFLS 2306_ NEKLP 2311_ NLECI 2316_ QNANK 2321_ GTHTS 2326_ LMQRL 2331_ RNRGE 2336_ RDRER 2341_ ERERE 2346_ MRRSS 2351_ GLRAG 2356_ SRRDR 2361_ DRDFR 2366_ RQLSI 2371_ DTRPF 2376_ RPASE 2381_ GNPSD 2386_ DPEPL 2391_ PAHRQ 2396_ ALGER 2401_ LYPRV 2406_ QAMQP 2411_ AFASK 2416_ ITGML 2421_ LELSP 2426_ AQLLL 2431_ LLASE 2436_ DSLRA 2441_ RVDEA 2446_ MELII 2451_ AHGRE 2456_ NGADS 2461_ ILDLG 2466_ LVDSS 2471_ EKVQQ 2476_ ENRKR 2481_ HGSSR 2486_ SVVDM 2491_ DLDDT 2496_ DDGDD 2501_ NAPLF 2506_ YQPGK 2511_ RGFYT 2516_ PRPGK 2521_ NTEAR 2526_ LNCFR 2531_ NIGRI 2536_ LGLCL 2541_ LQNEL 2546_ CPITL 2551_ NRHVI 2556_ KVLLG 2561_ RKVNW 2566_ HDFAF 2571_ FDPVM 2576_ YESLR 2581_ QLILA 2586_ SQSSD 2591_ ADAVF 2596_ SAMDL 2601_ AFAID 2606_ LCKEE 2611_ GGGQV 2616_ ELIPN 2621_ GVNIP 2626_ VTPQN 2631_ VYEYV 2636_ RKYAE 2641_ HRMLV 2646_ VAEQP 2651_ LHAMR 2656_ KGLLD 2661_ VLPKN 2666_ SLEDL 2671_ TAEDF 2676_ RLLVN 2681_ GCGEV 2686_ NVQML 2691_ ISFTS 2696_ FNDES 2701_ GENAE 2706_ KLLQF 2711_ KRWFW 2716_ SIVEK 2721_ MSMTE 2726_ RQDLV 2731_ YFWTS 2736_ SPSLP 2741_ ASEEG 2746_ FQPMP 2751_ SITIR 2756_ PPDDQ 2761_ HLPTA 2766_ NTCIS 2771_ RLYVP 2776_ LYSSK 2781_ QILKQ 2786_ KLLLA 2791_IKTKN
1: E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity)