SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)
1_MDAVN 6_ AFNQE 11_ LFSLM 16_ DMKPP 21_ ISRAK 26_ MILIT 31_ KAAIK 36_ AIKLY 41_ KHVVQ 46_ IVEKF 51_ IKKCK 56_ PEYKV 61_ PGLYV 66_ IDSIV 71_ RQSRH 76_ QFGTD 81_ KDVFG 86_ PRFSK 91_ NITAT 96_ FQYLY 101_ LCPSE 106_ DKSKI 111_ VRVLN 116_ LWQKN 121_ GVFKI 126_ EIIQP 131_ LLDMA 136_ AGTSN 141_ AAPVA 146_ ENVTN 151_ NEGSP 156_ PPPVK 161_ VSSEP 166_ PTQAT 171_ PNSVP 176_ AVPQL 181_ PSSDA 186_ FAAVA 191_ QLFQT 196_ TQGQQ 201_ LQQIL 206_ QTFQQ 211_ PPKPQ 216_ SPALD 221_ NAVMA 226_ QVQAI 231_ TAQLK 236_ TTPTQ 241_ PSEQK 246_ AAFPP 251_ PEQKT 256_ AFDKK 261_ LLDRF 266_ DYDDE 271_ PEAVE 276_ ESKKE 281_ DTTAV 286_ TTTAP 291_ AAAVP 296_ PAPTA 301_ TVPAA 306_ AAPAA 311_ ASPPP 316_ PQAPF 321_ GFPGD 326_ GMQQP 331_ AYTQH 336_ QNMDQ 341_ FQPRM 346_ MGIQQ 351_ DPMHH 356_ QVPLP 361_ PNGQM 366_ PGFGL 371_ LPTPP 376_ FPPMA 381_ QPVIP 386_ PTPPV 391_ QQPFQ 396_ ASFQA 401_ QNEPL 406_ TQKPH 411_ QQEME 416_ VEQPC 421_ IQEVK 426_ RHMSD 431_ NRKSR 436_ SRSAS 441_ RSPKR 446_ RRSRS 451_ GSRSR 456_ RSRHR 461_ RSRSR 466_ SRDRR 471_ RHSPR 476_ SRSQE 481_ RRDRE 486_ KERER 491_ RQKGL 496_ PQVKP 501_ ETASV 506_ CSTTL 511_ WVGQL 516_ DKRTT 521_ QQDVA 526_ SLLEE 531_ FGPIE 536_ SINMI 541_ PPRGC 546_ AYIVM 551_ VHRQD 556_ AYRAL 561_ QKLSR 566_ GNYKV 571_ NQKSI 576_ KIAWA 581_ LNKGI 586_ KADYK 591_ QYWDV 596_ ELGVT 601_ YIPWD 606_ KVKPE 611_ ELESF 616_ CEGGM 621_ LDSDT 626_ LNPDW 631_ KGIPK 636_ KPENE 641_ VAQNG 646_ GAETS 651_ HTEPV 656_ SPIPK 661_ PLPVP 666_ VPPIP 671_ VPAPI 676_ TVPPP 681_ QVPPH 686_ QPGPP 691_ VVGAL 696_ QPPAF 701_ TPPLG 706_ IPPPG 711_ FGPGV 716_ PPPPP 721_ PPPFL 726_ RPGFN 731_ PMHLP 736_ PGFLP 741_ PGPPP 746_ PITPP 751_ VSIPP 756_ PHTPP 761_ ISIPN 766_ STIAG 771_ INEDT 776_ TKDLS 781_ IGNPI 786_ PTVVS 791_ GARGN 796_ AESGD 801_ SVKMY 806_ GSAVP 811_ PAAPT 816_ NLPTP 821_ PVTQP 826_ VSLLG 831_ TQGVA 836_ PGPVI 841_ GLQAP 846_ STGLL 851_ GARPG 856_ LIPLQ 861_ RPPGM 866_ PPPHL 871_ QRFPL 876_ MPPRP 881_ MPPHM 886_ MHRGP 891_ PPGPG 896_ GFAMP 901_ PPHGM 906_ KGPFP 911_ PHGPF 916_ VRPGG 921_ MPGLG 926_ GPGPG 931_ PGGPE 936_ DRDGR 941_ QQPPQ 946_ QPQQQ 951_ PQPQA 956_ PQQPQ 961_ QQQQQ 966_ QPPPS 971_ QQPPP 976_ TQQQP 981_ QQFRN 986_ DNRQQ 991_ FNSGR 996_ DQERF 1001_ GRRSF 1006_ GNRVE 1011_ NDRER 1016_ YGNRN 1021_ DDRDN 1026_ SNRDR 1031_ REWGR 1036_ RSPDR 1041_ DRHRD 1046_ LEERN 1051_ RRSSG 1056_ HRDRE 1061_ RDSRD 1066_ RESRR 1071_ EKEEA 1076_ RGKEK 1081_ PEVTD 1086_ RAGGN 1091_ KTVEP 1096_ PISQV 1101_ GNVDT 1106_ ASELE 1111_ KGVSE 1116_ AAVLK 1121_ PSEEL 1126_ PAEAT 1131_ SSVEP 1136_ EKDSG 1141_SAAEA
1: Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839)