Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)
1_MSLLF 6_ SRCNS 11_ IVTVK 16_ KNKRH 21_ MAEVN 26_ ASPLK 31_ HFVTA 36_ KKKIN 41_ GIFEQ 46_ LGAYI 51_ QESAT 56_ FLEDT 61_ YRNAE 66_ LDPVT 71_ TEEQV 76_ LDVKG 81_ YLSKV 86_ RGISE 91_ VLARR 96_ HMKVA 101_ FFGRT 106_ SNGKS 111_ TVINA 116_ MLWDK 121_ VLPSG 126_ IGHTT 131_ NCFLR 136_ VEGTD 141_ GHEAF 146_ LLTEG 151_ SEEKR 156_ SAKTV 161_ NQLAH 166_ ALHQD 171_ KQLHA 176_ GSLVS 181_ VMWPN 186_ SKCPL 191_ LKDDL 196_ VLMDS 201_ PGIDV 206_ TTELD 211_ SWIDK 216_ FCLDA 221_ DVFVL 226_ VANSE 231_ STLMQ 236_ TEKHF 241_ FHKVS 246_ ERLSR 251_ PNIFI 256_ LNNRW 261_ DASAS 266_ EPEYM 271_ EEVRR 276_ QHMER 281_ CTSFL 286_ VDELG 291_ VVDRS 296_ QAGDR 301_ IFFVS 306_ AKEVL 311_ NARIQ 316_ KAQGM 321_ PEGGG 326_ ALAEG 331_ FQVRM 336_ FEFQN 341_ FERRF 346_ EECIS 351_ QSAVK 356_ TKFEQ 361_ HTVRA 366_ KQIAE 371_ AVRLI 376_ MDSLH 381_ MAARE 386_ QQVYC 391_ EEMRE 396_ ERQDR 401_ LKFID 406_ KQLEL 411_ LAQDY 416_ KLRIK 421_ QITEE 426_ VERQV 431_ STAMA 436_ EEIRR 441_ LSVLV 446_ DDYQM 451_ DFHPS 456_ PVVLK 461_ VYKNE 466_ LHRHI 471_ EEGLG 476_ RNMSD 481_ RCSTA 486_ ITNSL 491_ QTMQQ 496_ DMIDG 501_ LKPLL 506_ PVSVR 511_ SQIDM 516_ LVPRQ 521_ CFSLN 526_ YDLNC 531_ DKLCA 536_ DFQED 541_ IEFHF 546_ SLGWT 551_ MLVNR 556_ FLGPK 561_ NSRRA 566_ LMGYN 571_ DQVQR 576_ PIPLT 581_ PANPS 586_ MPPLP 591_ QGSLT 596_ QEEFM 601_ VSMVT 606_ GLASL 611_ TSRTS 616_ MGILV 621_ VGGVV 626_ WKAVG 631_ WRLIA 636_ LSFGL 641_ YGLLY 646_ VYERL 651_ TWTTK 656_ AKERA 661_ FKRQF 666_ VEHAS 671_ EKLQL 676_ VISYT 681_ GSNCS 686_ HQVQQ 691_ ELSGT 696_ FAHLC 701_ QQVDV 706_ TRENL 711_ EQEIA 716_ AMNKK 721_ IEVLD 726_ SLQSK 731_ AKLLR 736_ NKAGW 741_ LDSEL 746_ NMFTH 751_QYLQP
1: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity)