Gene name: DUSP14

Uniprot entry:

O95147

Protein names:

Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)

Protein sequence:

1_MSSRG 6_ HSTLP 11_ RTLMA 16_ PRMIS 21_ EGDIG 26_ GIAQI 31_ TSSLF 36_ LGRGS 41_ VASNR 46_ HLLQA 51_ RGITC 56_ IVNAT 61_ IEIPN 66_ FNWPQ 71_ FEYVK 76_ VPLAD 81_ MPHAP 86_ IGLYF 91_ DTVAD 96_ KIHSV 101_ SRKHG 106_ ATLVH 111_ CAAGV 116_ SRSAT 121_ LCIAY 126_ LMKFH 131_ NVCLL 136_ EAYNW 141_ VKARR 146_ PVIRP 151_ NVGFW 156_ RQLID 161_ YERQL 166_ FGKST 171_ VKMVQ 176_ TPYGI 181_ VPDVY 186_ EKESR 191_HLMPY

Protein annotations

Protein functions:

1: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation (PubMed:24403530)