Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1 aldehyde reductase 2) (AFB1-AR 2)
1_MSRQL 6_ SRARP 11_ ATVLG 16_ AMEMG 21_ RRMDA 26_ PTSAA 31_ VTRAF 36_ LERGH 41_ TEIDT 46_ AFVYS 51_ EGQSE 56_ TILGG 61_ LGLRL 66_ GGSDC 71_ RVKID 76_ TKAIP 81_ LFGNS 86_ LKPDS 91_ LRFQL 96_ ETSLK 101_ RLQCP 106_ RVDLF 111_ YLHMP 116_ DHSTP 121_ VEETL 126_ RACHQ 131_ LHQEG 136_ KFVEL 141_ GLSNY 146_ AAWEV 151_ AEICT 156_ LCKSN 161_ GWILP 166_ TVYQG 171_ MYNAI 176_ TRQVE 181_ TELFP 186_ CLRHF 191_ GLRFY 196_ AFNPL 201_ AGGLL 206_ TGKYK 211_ YEDKN 216_ GKQPV 221_ GRFFG 226_ NTWAE 231_ MYRNR 236_ YWKEH 241_ HFEGI 246_ ALVEK 251_ ALQAA 256_ YGASA 261_ PSMTS 266_ ATLRW 271_ MYHHS 276_ QLQGA 281_ HGDAV 286_ ILGMS 291_ SLEQL 296_ EQNLA 301_ AAEEG 306_ PLEPA 311_ VVDAF 316_ NQAWH 321_ LVTHE 326_CPNYF
1: Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity