Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
1_MKFVY 6_ KEEHP 11_ FEKRR 16_ SEGEK 21_ IRKKY 26_ PDRVP 31_ VIVEK 36_ APKAR 41_ IGDLD 46_ KKKYL 51_ VPSDL 56_ TVGQF 61_ YFLIR 66_ KRIHL 71_ RAEDA 76_ LFFFV 81_ NNVIP 86_ PTSAT 91_ MGQLY 96_ QEHHE 101_ EDFFL 106_ YIAYS 111_DESVY
1: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068)