Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)
1_MRKGL 6_ RATAA 11_ RCGLG 16_ LGYLL 21_ QMLVL 26_ PALAL 31_ LSASG 36_ TGSAA 41_ QDDDF 46_ FHELP 51_ ETFPS 56_ DPPEP 61_ LPHFL 66_ IEPEE 71_ AYIVK 76_ NKPVN 81_ LYCKA 86_ SPATQ 91_ IYFKC 96_ NSEWV 101_ HQKDH 106_ IVDER 111_ VDETS 116_ GLIVR 121_ EVSIE 126_ ISRQQ 131_ VEELF 136_ GPEDY 141_ WCQCV 146_ AWSSA 151_ GTTKS 156_ RKAYV 161_ RIAYL 166_ RKTFE 171_ QEPLG 176_ KEVSL 181_ EQEVL 186_ LQCRP 191_ PEGIP 196_ VAEVE 201_ WLKNE 206_ DIIDP 211_ VEDRN 216_ FYITI 221_ DHNLI 226_ IKQAR 231_ LSDTA 236_ NYTCV 241_ AKNIV 246_ AKRKS 251_ TTATV 256_ IVYVN 261_ GGWST 266_ WTEWS 271_ VCNSR 276_ CGRGY 281_ QKRTR 286_ TCTNP 291_ APLNG 296_ GAFCE 301_ GQSVQ 306_ KIACT 311_ TLCPV 316_ DGRWT 321_ PWSKW 326_ STCGT 331_ ECTHW 336_ RRREC 341_ TAPAP 346_ KNGGK 351_ DCDGL 356_ VLQSK 361_ NCTDG 366_ LCMQT 371_ APDSD 376_ DVALY 381_ VGIVI 386_ AVIVC 391_ LAISV 396_ VVALF 401_ VYRKN 406_ HRDFE 411_ SDIID 416_ SSALN 421_ GGFQP 426_ VNIKA 431_ ARQDL 436_ LAVPP 441_ DLTSA 446_ AAMYR 451_ GPVYA 456_ LHDVS 461_ DKIPM 466_ TNSPI 471_ LDPLP 476_ NLKIK 481_ VYNTS 486_ GAVTP 491_ QDDLS 496_ EFTSK 501_ LSPQM 506_ TQSLL 511_ ENEAL 516_ SLKNQ 521_ SLARQ 526_ TDPSC 531_ TAFGS 536_ FNSLG 541_ GHLIV 546_ PNSGV 551_ SLLIP 556_ AGAIP 561_ QGRVY 566_ EMYVT 571_ VHRKE 576_ TMRPP 581_ MDDSQ 586_ TLLTP 591_ VVSCG 596_ PPGAL 601_ LTRPV 606_ VLTMH 611_ HCADP 616_ NTEDW 621_ KILLK 626_ NQAAQ 631_ GQWED 636_ VVVVG 641_ EENFT 646_ TPCYI 651_ QLDAE 656_ ACHIL 661_ TENLS 666_ TYALV 671_ GHSTT 676_ KAAAK 681_ RLKLA 686_ IFGPL 691_ CCSSL 696_ EYSIR 701_ VYCLD 706_ DTQDA 711_ LKEIL 716_ HLERQ 721_ MGGQL 726_ LEEPK 731_ ALHFK 736_ GSTHN 741_ LRLSI 746_ HDIAH 751_ SLWKS 756_ KLLAK 761_ YQEIP 766_ FYHVW 771_ SGSQR 776_ NLHCT 781_ FTLER 786_ FSLNT 791_ VELVC 796_ KLCVR 801_ QVEGE 806_ GQIFQ 811_ LNCTV 816_ SEEPT 821_ GIDLP 826_ LLDPA 831_ NTITT 836_ VTGPS 841_ AFSIP 846_ LPIRQ 851_ KLCSS 856_ LDAPQ 861_ TRGHD 866_ WRMLA 871_ HKLNL 876_ DRYLN 881_ YFATK 886_ SSPTG 891_ VILDL 896_ WEAQN 901_ FPDGN 906_ LSMLA 911_ AVLEE 916_ MGRHE 921_ TVVSL 926_AAEGQ
1: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity)