Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)
1_MINTQ 6_ DSSIL 11_ PLSNC 16_ PQLQC 21_ CRHIV 26_ PGPLW 31_ CSDAP 36_ HPLSK 41_ IPGGR 46_ GGGRD 51_ PSLSA 56_ LIYKD 61_ EKLTV 66_ TQDLP 71_ VNDGK 76_ PHIVH 81_ FQYEV 86_ TEVKV 91_ SSWDA 96_ VLSSQ 101_ SLFVE 106_ IPDGL 111_ LADGS 116_ KEGLL 121_ ALLEF 126_ AEEKM 131_ KVNYV 136_ FICFR 141_ KGRED 146_ RAPLL 151_ KTFSF 156_ LGFEI 161_ VRPGH 166_ PCVPS 171_ RPDVM 176_ FMVYP 181_LDQNL
1: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity)