Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)
1_MAEPS 6_ AATQS 11_ HSISS 16_ SSFGA 21_ EPSAP 26_ GGGGS 31_ PGACP 36_ ALGTK 41_ SCSSS 46_ CADSF 51_ VSSSS 56_ SQPVS 61_ LFSTS 66_ QEGLS 71_ SLCSD 76_ EPSSE 81_ IMTSS 86_ FLSSS 91_ EIHNT 96_ GLTIL 101_ HGEKS 106_ HVLGS 111_ QPILA 116_ KEGKD 121_ HLDLL 126_ DMKKM 131_ EKPQG 136_ TSNNV 141_ SDSSV 146_ SLAAG 151_ VHCDR 156_ PSIPA 161_ SFPEH 166_ PAFLS 171_ KKIGQ 176_ VEEQI 181_ DKETK 186_ NPNGV 191_ SSREA 196_ KTALD 201_ ADDRF 206_ TLLTA 211_ QKPPT 216_ EYSKV 221_ EGIYT 226_ YSLSP 231_ SKVSG 236_ DDVIE 241_ KDSPE 246_ SPFEV 251_ IIDKA 256_ AFDKE 261_ FKDSY 266_ KESTD 271_ DFGSW 276_ SVHTD 281_ KESSE 286_ DISET 291_ NDKLF 296_ PLRNK 301_ EAGRY 306_ PMSAL 311_ LSRQF 316_ SHTNA 321_ ALEEV 326_ SRCVN 331_ DMHNF 336_ TNEIL 341_ TWDLV 346_ PQVKQ 351_ QTDKS 356_ SDCIT 361_ KTTGL 366_ DMSEY 371_ NSEIP 376_ VVNLK 381_ TSTHQ 386_ KTPVC 391_ SIDGS 396_ TPITK 401_ STGDW 406_ AEASL 411_ QQENA 416_ ITGKP 421_ VPDSL 426_ NSTKE 431_ FSIKG 436_ VQGNM 441_ QKQDD 446_ TLAEL 451_ PGSPP 456_ EKCDS 461_ LGSGV 466_ ATVKV 471_ VLPDD 476_ HLKDE 481_ MDWQS 486_ SALGE 491_ ITEAD 496_ SSGES 501_ DDTVI 506_ EDITA 511_ DTSFE 516_ NNKIQ 521_ AEKPV 526_ SIPSA 531_ VVKTG 536_ EREIK 541_ EIPSC 546_ EREEK 551_ TSKNF 556_ EELVS 561_ DSELH 566_ QDQPD 571_ ILGRS 576_ PASEA 581_ ACSKV 586_ PDTNV 591_ SLEDV 596_ SEVAP 601_ EKPIT 606_ TENPK 611_ LPSTV 616_ SPNVF 621_ NETEF 626_ SLNVT 631_ TSAYL 636_ ESLHG 641_ KNVKH 646_ IDDSS 651_ PEDLI 656_ AAFTE 661_ TRDKG 666_ IVDSE 671_ RNAFK 676_ AISEK 681_ MTDFK 686_ TTPPV 691_ EVLHE 696_ NESGG 701_ SEIKD 706_ IGSKY 711_ SEQSK 716_ ETNGS 721_ EPLGV 726_ FPTQG 731_ TPVAS 736_ LDLEQ 741_ EQLTI 746_ KALKE 751_ LGERQ 756_ VEKST 761_ SAQRD 766_ AELPS 771_ EEVLK 776_ QTFTF 781_ APESW 786_ PQRSY 791_ DILER 796_ NVKNG 801_ SDLGI 806_ SQKPI 811_ TIRET 816_ TRVDA 821_ VSSLS 826_ KTELV 831_ KKHVL 836_ ARLLT 841_ DFSVH 846_ DLIFW 851_ RDVKK 856_ TGFVF 861_ GTTLI 866_ MLLSL 871_ AAFSV 876_ ISVVS 881_ YLILA 886_ LLSVT 891_ ISFRI 896_ YKSVI 901_ QAVQK 906_ SEEGH 911_ PFKAY 916_ LDVDI 921_ TLSSE 926_ AFHNY 931_ MNAAM 936_ VHINR 941_ ALKLI 946_ IRLFL 951_ VEDLV 956_ DSLKL 961_ AVFMW 966_ LMTYV 971_ GAVFN 976_ GITLL 981_ ILAEL 986_ LIFSV 991_ PIVYE 996_ KYKTQ 1001_ IDHYV 1006_ GIARD 1011_ QTKSI 1016_ VEKIQ 1021_ AKLPG 1026_IAKKK
1: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition
2: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses