Kelch-like protein 2 (Actin-binding protein Mayven)
1_METPP 6_ LPPAC 11_ TKQGH 16_ QKPLD 21_ SKDDN 26_ TEKHC 31_ PVTVN 36_ PWHMK 41_ KAFKV 46_ MNELR 51_ SQNLL 56_ CDVTI 61_ VAEDM 66_ EISAH 71_ RVVLA 76_ ACSPY 81_ FHAMF 86_ TGEMS 91_ ESRAK 96_ RVRIK 101_ EVDGW 106_ TLRML 111_ IDYVY 116_ TAEIQ 121_ VTEEN 126_ VQVLL 131_ PAAGL 136_ LQLQD 141_ VKKTC 146_ CEFLE 151_ SQLHP 156_ VNCLG 161_ IRAFA 166_ DMHAC 171_ TDLLN 176_ KANTY 181_ AEQHF 186_ ADVVL 191_ SEEFL 196_ NLGIE 201_ QVCSL 206_ ISSDK 211_ LTISS 216_ EEKVF 221_ EAVIA 226_ WVNHD 231_ KDVRQ 236_ EFMAR 241_ LMEHV 246_ RLPLL 251_ PREYL 256_ VQRVE 261_ EEALV 266_ KNSSA 271_ CKDYL 276_ IEAMK 281_ YHLLP 286_ TEQRI 291_ LMKSV 296_ RTRLR 301_ TPMNL 306_ PKLMV 311_ VVGGQ 316_ APKAI 321_ RSVEC 326_ YDFKE 331_ ERWHQ 336_ VAELP 341_ SRRCR 346_ AGMVY 351_ MAGLV 356_ FAVGG 361_ FNGSL 366_ RVRTV 371_ DSYDP 376_ VKDQW 381_ TSVAN 386_ MRDRR 391_ STLGA 396_ AVLNG 401_ LLYAV 406_ GGFDG 411_ STGLS 416_ SVEAY 421_ NIKSN 426_ EWFHV 431_ APMNT 436_ RRSSV 441_ GVGVV 446_ GGLLY 451_ AVGGY 456_ DGASR 461_ QCLST 466_ VECYN 471_ ATTNE 476_ WTYIA 481_ EMSTR 486_ RSGAG 491_ VGVLN 496_ NLLYA 501_ VGGHD 506_ GPLVR 511_ KSVEV 516_ YDPTT 521_ NAWRQ 526_ VADMN 531_ MCRRN 536_ AGVCA 541_ VNGLL 546_ YVVGG 551_ DDGSC 556_ NLASV 561_ EYYNP 566_ TTDKW 571_ TVVSS 576_ CMSTG 581_ RSYAG 586_VTVID
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:23838290). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (PubMed:23838290). Plays a role in the reorganization of the actin cytoskeleton (PubMed:10397770). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669)