Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase)
1_MKNPM 6_ LEVVS 11_ LLLEK 16_ LLLIS 21_ NFTLF 26_ SSGAA 31_ GEDKG 36_ RNSFY 41_ ETSSF 46_ HRGDV 51_ LEVPR 56_ THLTH 61_ YGIYL 66_ GDNRV 71_ AHMMP 76_ DILLA 81_ LTDDM 86_ GRTQK 91_ VVSNK 96_ RLILG 101_ VIVKV 106_ ASIRV 111_ DTVED 116_ FAYGA 121_ NILVN 126_ HLDES 131_ LQKKA 136_ LLNEE 141_ VARRA 146_ EKLLG 151_ FTPYS 156_ LLWNN 161_ CEHFV 166_ TYCRY 171_ GTPIS 176_ PQSDK 181_ FCETV 186_ KIIIR 191_ DQRSV 196_ LASAV 201_ LGLAS 206_ IVCTG 211_ LVSYT 216_ TLPAI 221_FIPFF
1: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity)