Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)
1_MPRRK 6_ RNAGS 11_ SSDGT 16_ EDSDF 21_ STDLE 26_ HTDSS 31_ ESDGT 36_ SRRSA 41_ RVTRS 46_ SARLS 51_ QSSQD 56_ SSPVR 61_ NLQSF 66_ GTEEP 71_ AYSTR 76_ RVTRS 81_ QQQPT 86_ PVTPK 91_ KYPLR 96_ QTRSS 101_ GSETE 106_ QVVDF 111_ SDRET 116_ KNTAD 121_ HDESP 126_ PRTPT 131_ GNAPS 136_ SESDI 141_ DISSP 146_ NVSHD 151_ ESIAK 156_ DMSLK 161_ DSGSD 166_ LSHRP 171_ KRRRF 176_ HESYN 181_ FNMKC 186_ PTPGC 191_ NSLGH 196_ LTGKH 201_ ERHFS 206_ ISGCP 211_ LYHNL 216_ SADEC 221_ KVRAQ 226_ SRDKQ 231_ IEERM 236_ LSHRQ 241_ DDNNR 246_ HATRH 251_ QAPTE 256_ RQLRY 261_ KEKVA 266_ ELRKK 271_ RNSGL 276_ SKEQK 281_ EKYME 286_ HRQTY 291_ GNTRE 296_ PLLEN 301_ LTSEY 306_ DLDLF 311_ RRAQA 316_ RASED 321_ LEKLR 326_ LQGQI 331_ TEGSN 336_ MIKTI 341_ AFGRY 346_ ELDTW 351_ YHSPY 356_ PEEYA 361_ RLGRL 366_ YMCEF 371_ CLKYM 376_ KSQTI 381_ LRRHM 386_ AKCVW 391_ KHPPG 396_ DEIYR 401_ KGSIS 406_ VFEVD 411_ GKKNK 416_ IYCQN 421_ LCLLA 426_ KLFLD 431_ HKTLY 436_ YDVEP 441_ FLFYV 446_ MTEAD 451_ NTGCH 456_ LIGYF 461_ SKEKN 466_ SFLNY 471_ NVSCI 476_ LTMPQ 481_ YMRQG 486_ YGKML 491_ IDFSY 496_ LLSKV 501_ EEKVG 506_ SPERP 511_ LSDLG 516_ LISYR 521_ SYWKE 526_ VLLRY 531_ LHNFQ 536_ GKEIS 541_ IKEIS 546_ QETAV 551_ NPVDI 556_ VSTLQ 561_ ALQML 566_ KYWKG 571_ KHLVL 576_ KRQDL 581_ IDEWI 586_ AKEAK 591_ RSNSN 596_ KTMDP 601_ SCLKW 606_TPPKG
1: Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280)
2: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282)