ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
1_MAAPA 6_ EPCAG 11_ QGVWN 16_ QTEPE 21_ PAATS 26_ LLSLC 31_ FLRTA 36_ GVWVP 41_ PMYLW 46_ VLGPI 51_ YLLFI 56_ HHHGR 61_ GYLRM 66_ SPLFK 71_ AKMVL 76_ GFALI 81_ VLCTS 86_ SVAVA 91_ LWKIQ 96_ QGTPE 101_ APEFL 106_ IHPTV 111_ WLTTM 116_ SFAVF 121_ LIHTE 126_ RKKGV 131_ QSSGV 136_ LFGYW 141_ LLCFV 146_ LPATN 151_ AAQQA 156_ SGAGF 161_ QSDPV 166_ RHLST 171_ YLCLS 176_ LVVAQ 181_ FVLSC 186_ LADQP 191_ PFFPE 196_ DPQQS 201_ NPCPE 206_ TGAAF 211_ PSKAT 216_ FWWVS 221_ GLVWR 226_ GYRRP 231_ LRPKD 236_ LWSLG 241_ RENSS 246_ EELVS 251_ RLEKE 256_ WMRNR 261_ SAARR 266_ HNKAI 271_ AFKRK 276_ GGSGM 281_ KAPET 286_ EPFLR 291_ QEGSQ 296_ WRPLL 301_ KAIWQ 306_ VFHST 311_ FLLGT 316_ LSLII 321_ SDVFR 326_ FTVPK 331_ LLSLF 336_ LEFIG 341_ DPKPP 346_ AWKGY 351_ LLAVL 356_ MFLSA 361_ CLQTL 366_ FEQQN 371_ MYRLK 376_ VLQMR 381_ LRSAI 386_ TGLVY 391_ RKVLA 396_ LSSGS 401_ RKASA 406_ VGDVV 411_ NLVSV 416_ DVQRL 421_ TESVL 426_ YLNGL 431_ WLPLV 436_ WIVVC 441_ FVYLW 446_ QLLGP 451_ SALTA 456_ IAVFL 461_ SLLPL 466_ NFFIS 471_ KKRNH 476_ HQEEQ 481_ MRQKD 486_ SRARL 491_ TSSIL 496_ RNSKT 501_ IKFHG 506_ WEGAF 511_ LDRVL 516_ GIRGQ 521_ ELGAL 526_ RTSGL 531_ LFSVS 536_ LVSFQ 541_ VSTFL 546_ VALVV 551_ FAVHT 556_ LVAEN 561_ AMNAE 566_ KAFVT 571_ LTVLN 576_ ILNKA 581_ QAFLP 586_ FSIHS 591_ LVQAR 596_ VSFDR 601_ LVTFL 606_ CLEEV 611_ DPGVV 616_ DSSSS 621_ GSAAG 626_ KDCIT 631_ IHSAT 636_ FAWSQ 641_ ESPPC 646_ LHRIN 651_ LTVPQ 656_ GCLLA 661_ VVGPV 666_ GAGKS 671_ SLLSA 676_ LLGEL 681_ SKVEG 686_ FVSIE 691_ GAVAY 696_ VPQEA 701_ WVQNT 706_ SVVEN 711_ VCFGQ 716_ ELDPP 721_ WLERV 726_ LEACA 731_ LQPDV 736_ DSFPE 741_ GIHTS 746_ IGEQG 751_ MNLSG 756_ GQKQR 761_ LSLAR 766_ AVYRK 771_ AAVYL 776_ LDDPL 781_ AALDA 786_ HVGQH 791_ VFNQV 796_ IGPGG 801_ LLQGT 806_ TRILV 811_ THALH 816_ ILPQA 821_ DWIIV 826_ LANGA 831_ IAEMG 836_ SYQEL 841_ LQRKG 846_ ALMCL 851_ LDQAR 856_ QPGDR 861_ GEGET 866_ EPGTS 871_ TKDPR 876_ GTSAG 881_ RRPEL 886_ RRERS 891_ IKSVP 896_ EKDRT 901_ TSEAQ 906_ TEVPL 911_ DDPDR 916_ AGWPA 921_ GKDSI 926_ QYGRV 931_ KATVH 936_ LAYLR 941_ AVGTP 946_ LCLYA 951_ LFLFL 956_ CQQVA 961_ SFCRG 966_ YWLSL 971_ WADDP 976_ AVGGQ 981_ QTQAA 986_ LRGGI 991_ FGLLG 996_ CLQAI 1001_ GLFAS 1006_ MAAVL 1011_ LGGAR 1016_ ASRLL 1021_ FQRLL 1026_ WDVVR 1031_ SPISF 1036_ FERTP 1041_ IGHLL 1046_ NRFSK 1051_ ETDTV 1056_ DVDIP 1061_ DKLRS 1066_ LLMYA 1071_ FGLLE 1076_ VSLVV 1081_ AVATP 1086_ LATVA 1091_ ILPLF 1096_ LLYAG 1101_ FQSLY 1106_ VVSSC 1111_ QLRRL 1116_ ESASY 1121_ SSVCS 1126_ HMAET 1131_ FQGST 1136_ VVRAF 1141_ RTQAP 1146_ FVAQN 1151_ NARVD 1156_ ESQRI 1161_ SFPRL 1166_ VADRW 1171_ LAANV 1176_ ELLGN 1181_ GLVFA 1186_ AATCA 1191_ VLSKA 1196_ HLSAG 1201_ LVGFS 1206_ VSAAL 1211_ QVTQT 1216_ LQWVV 1221_ RNWTD 1226_ LENSI 1231_ VSVER 1236_ MQDYA 1241_ WTPKE 1246_ APWRL 1251_ PTCAA 1256_ QPPWP 1261_ QGGQI 1266_ EFRDF 1271_ GLRYR 1276_ PELPL 1281_ AVQGV 1286_ SFKIH 1291_ AGEKV 1296_ GIVGR 1301_ TGAGK 1306_ SSLAS 1311_ GLLRL 1316_ QEAAE 1321_ GGIWI 1326_ DGVPI 1331_ AHVGL 1336_ HTLRS 1341_ RISII 1346_ PQDPI 1351_ LFPGS 1356_ LRMNL 1361_ DLLQE 1366_ HSDEA 1371_ IWAAL 1376_ ETVQL 1381_ KALVA 1386_ SLPGQ 1391_ LQYKC 1396_ ADRGE 1401_ DLSVG 1406_ QKQLL 1411_ CLARA 1416_ LLRKT 1421_ QILIL 1426_ DEATA 1431_ AVDPG 1436_ TELQM 1441_ QAMLG 1446_ SWFAQ 1451_ CTVLL 1456_ IAHRL 1461_ RSVMD 1466_ CARVL 1471_ VMDKG 1476_ QVAES 1481_ GSPAQ 1486_ LLAQK 1491_ GLFYR 1496_LAQES
1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644)
2: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis
3: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases