Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Voltage-gated potassium channel subunit Kv10.1)
1_MTMAG 6_ GRRGL 11_ VAPQN 16_ TFLEN 21_ IVRRS 26_ NDTNF 31_ VLGNA 36_ QIVDW 41_ PIVYS 46_ NDGFC 51_ KLSGY 56_ HRAEV 61_ MQKSS 66_ TCSFM 71_ YGELT 76_ DKDTI 81_ EKVRQ 86_ TFENY 91_ EMNSF 96_ EILMY 101_ KKNRT 106_ PVWFF 111_ VKIAP 116_ IRNEQ 121_ DKVVL 126_ FLCTF 131_ SDITA 136_ FKQPI 141_ EDDSC 146_ KGWGK 151_ FARLT 156_ RALTS 161_ SRGVL 166_ QQLAP 171_ SVQKG 176_ ENVHK 181_ HSRLA 186_ EVLQL 191_ GSDIL 196_ PQYKQ 201_ EAPKT 206_ PPHII 211_ LHYCV 216_ FKTTW 221_ DWIIL 226_ ILTFY 231_ TAILV 236_ PYNVS 241_ FKTRQ 246_ NNVAW 251_ LVVDS 256_ IVDVI 261_ FLVDI 266_ VLNFH 271_ TTFVG 276_ PAGEV 281_ ISDPK 286_ LIRMN 291_ YLKTW 296_ FVIDL 301_ LSCLP 306_ YDVIN 311_ AFENV 316_ DEVSA 321_ FMGDP 326_ GKIGF 331_ ADQIP 336_ PPLEG 341_ RESQG 346_ ISSLF 351_ SSLKV 356_ VRLLR 361_ LGRVA 366_ RKLDH 371_ YIEYG 376_ AAVLV 381_ LLVCV 386_ FGLAA 391_ HWMAC 396_ IWYSI 401_ GDYEI 406_ FDEDT 411_ KTIRN 416_ NSWLY 421_ QLAMD 426_ IGTPY 431_ QFNGS 436_ GSGKW 441_ EGGPS 446_ KNSVY 451_ ISSLY 456_ FTMTS 461_ LTSVG 466_ FGNIA 471_ PSTDI 476_ EKIFA 481_ VAIMM 486_ IGSLL 491_ YATIF 496_ GNVTT 501_ IFQQM 506_ YANTN 511_ RYHEM 516_ LNSVR 521_ DFLKL 526_ YQVPK 531_ GLSER 536_ VMDYI 541_ VSTWS 546_ MSRGI 551_ DTEKV 556_ LQICP 561_ KDMRA 566_ DICVH 571_ LNRKV 576_ FKEHP 581_ AFRLA 586_ SDGCL 591_ RALAM 596_ EFQTV 601_ HCAPG 606_ DLIYH 611_ AGESV 616_ DSLCF 621_ VVSGS 626_ LEVIQ 631_ DDEVV 636_ AILGK 641_ GDVFG 646_ DVFWK 651_ EATLA 656_ QSCAN 661_ VRALT 666_ YCDLH 671_ VIKRD 676_ ALQKV 681_ LEFYT 686_ AFSHS 691_ FSRNL 696_ ILTYN 701_ LRKRI 706_ VFRKI 711_ SDVKR 716_ EEEER 721_ MKRKN 726_ EAPLI 731_ LPPDH 736_ PVRRL 741_ FQRFR 746_ QQKEA 751_ RLAAE 756_ RGGRD 761_ LDDLD 766_ VEKGN 771_ VLTEH 776_ ASANH 781_ SLVKA 786_ SVVTV 791_ RESPA 796_ TPVSF 801_ QAAST 806_ SGVPD 811_ HAKLQ 816_ APGSE 821_ CLGPK 826_ GGGGD 831_ CAKRK 836_ SWARF 841_ KDACG 846_ KSEDW 851_ NKVSK 856_ AESME 861_ TLPER 866_ TKASG 871_ EATLK 876_ KTDSC 881_ DSGIT 886_ KSDLR 891_ LDNVG 896_ EARSP 901_ QDRSP 906_ ILAEV 911_ KHSFY 916_ PIPEQ 921_ TLQAT 926_ VLEVR 931_ HELKE 936_ DIKAL 941_ NAKMT 946_ NIEKQ 951_ LSEIL 956_ RILTS 961_ RRSSQ 966_ SPQEL 971_ FEISR 976_ PQSPE 981_SERDI
1: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642)