RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein)
1_MGTLG 6_ KAREA 11_ PRKPS 16_ HGCRA 21_ ASKAR 26_ LEAKP 31_ ANSPF 36_ PSHPS 41_ LAHIT 46_ QFRMM 51_ VSLGH 56_ LAKGA 61_ SLDDL 66_ IDSCI 71_ QSFDA 76_ DGNLC 81_ RSNQL 86_ LQVML 91_ TMHRI 96_ VISSA 101_ ELLQK 106_ VITLY 111_ KDALA 116_ KNSPG 121_ LCLKI 126_ CYFVR 131_ YWITE 136_ FWVMF 141_ KMDAS 146_ LTDTM 151_ EEFQE 156_ LVKAK 161_ GEELH 166_ CRLID 171_ TTQIN 176_ ARDWS 181_ RKLTQ 186_ RIKSN 191_ TSKKR 196_ KVSLL 201_ FDHLE 206_ PEELS 211_ EHLTY 216_ LEFKS 221_ FRRIS 226_ FSDYQ 231_ NYLVN 236_ SCVKE 241_ NPTME 246_ RSIAL 251_ CNGIS 256_ QWVQL 261_ MVLSR 266_ PTPQL 271_ RAEVF 276_ IKFIQ 281_ VAQKL 286_ HQLQN 291_ FNTLM 296_ AVIGG 301_ LCHSS 306_ ISRLK 311_ ETSSH 316_ VPHEI 321_ NKVLG 326_ EMTEL 331_ LSSSR 336_ NYDNY 341_ RRAYG 346_ ECTDF 351_ KIPIL 356_ GVHLK 361_ DLISL 366_ YEAMP 371_ DYLED 376_ GKVNV 381_ HKLLA 386_ LYNHI 391_ SELVQ 396_ LQEVA 401_ PPLEA 406_ NKDLV 411_ HLLTL 416_ SLDLY 421_ YTEDE 426_ IYELS 431_ YAREP 436_ RNHRA 441_ PPLTP 446_ SKPPV 451_ VVDWA 456_ SGVSP 461_ KPDPK 466_ TISKH 471_ VQRMV 476_ DSVFK 481_ NYDHD 486_ QDGYI 491_ SQEEF 496_ EKIAA 501_ SFPFS 506_ FCVMD 511_ KDREG 516_ LISRD 521_ EITAY 526_ FMRAS 531_ SIYSK 536_ LGLGF 541_ PHNFQ 546_ ETTYL 551_ KPTFC 556_ DNCAG 561_ FLWGV 566_ IKQGY 571_ RCKDC 576_ GMNCH 581_ KQCKD 586_ LVVFE 591_ CKKRA 596_ KNPVA 601_ PTENN 606_ TSVGP 611_ VSNLC 616_ SLGAK 621_ DLLHA 626_ PEEGP 631_ FTFPN 636_ GEAVE 641_ HGEES 646_ KDRTI 651_ MLMGV 656_ SSQKI 661_ SLRLK 666_ RAVAH 671_ KATQT 676_ ESQPW 681_ IGSEG 686_ PSGPF 691_ VLSSP 696_ RKTAQ 701_ DTLYV 706_ LPSPT 711_ SPCPS 716_ PVLVR 721_ KRAFV 726_ KWENK 731_ DSLIK 736_ SKEEL 741_ RHLRL 746_ PTYQE 751_ LEQEI 756_ NTLKA 761_ DNDAL 766_ KIQLK 771_ YAQKK 776_ IESLQ 781_ LEKSN 786_ HVLAQ 791_MEQGD
1: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332)