Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid)
1_MASAT 6_ APAAA 11_ VPTLA 16_ SPLEQ 21_ LRHLA 26_ EELRL 31_ LLPRV 36_ RVGEA 41_ QETTE 46_ EFNRE 51_ MFWRR 56_ LNEAA 61_ VTVSR 66_ EATTL 71_ TIVFS 76_ QLPLP 81_ SPQET 86_ QKFCE 91_ QVHAA 96_ IKAFI 101_ AVYYL 106_ LPKDQ 111_ GITLR 116_ KLVRG 121_ ATLDI 126_ VDGMA 131_ QLMEV 136_ LSVTP 141_ TQSPE 146_ NNDLI 151_ SYNSV 156_ WVACQ 161_ QMPQI 166_ PRDNK 171_ AAALL 176_ MLTKN 181_ VDFVK 186_ DAHEE 191_ MEQAV 196_ EECDP 201_ YSGLL 206_ NDTEE 211_ NNSDN 216_ HNHED 221_ DVLGF 226_ PSNQD 231_ LYWSE 236_ DDQEL 241_ IIPCL 246_ ALVRA 251_ SKACL 256_ KKIRM 261_ LVAEN 266_ GKKDQ 271_ VAQLD 276_ DIVDI 281_ SDEIS 286_ PSVDD 291_ LALSI 296_ YPPMC 301_ HLTVR 306_ INSAK 311_ LVSVL 316_ KKALE 321_ ITKAS 326_ HVTPQ 331_ PEDSW 336_ IPLLI 341_ NAIDH 346_ CMNRI 351_KELTQ
1: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription