Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
1_MAKVE 6_ QVLSL 11_ EPQHE 16_ LKFRG 21_ PFTDV 26_ VTTNL 31_ KLGNP 36_ TDRNV 41_ CFKVK 46_ TTAPR 51_ RYCVR 56_ PNSGI 61_ IDAGA 66_ SINVS 71_ VMLQP 76_ FDYDP 81_ NEKSK 86_ HKFMV 91_ QSMFA 96_ PTDTS 101_ DMEAV 106_ WKEAK 111_ PEDLM 116_ DSKLR 121_ CVFEL 126_ PAEND 131_ KPHDV 136_ EINKI 141_ ISTTA 146_ SKTET 151_ PIVSK 156_ SLSSS 161_ LDDTE 166_ VKKVM 171_ EECKR 176_ LQGEV 181_ QRLRE 186_ ENKQF 191_ KEEDG 196_ LRMRK 201_ TVQSN 206_ SPISA 211_ LAPTG 216_ KEEGL 221_ STRLL 226_ ALVVL 231_ FFIVG 236_VIIGK
1: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369)