Myelin protein zero-like protein 1 (Protein zero-related)
1_MAASA 6_ GAGAV 11_ IAAPD 16_ SRRWL 21_ WSVLA 26_ AALGL 31_ LTAGV 36_ SALEV 41_ YTPKE 46_ IFVAN 51_ GTQGK 56_ LTCKF 61_ KSTST 66_ TGGLT 71_ SVSWS 76_ FQPEG 81_ ADTTV 86_ SFFHY 91_ SQGQV 96_ YLGNY 101_ PPFKD 106_ RISWA 111_ GDLDK 116_ KDASI 121_ NIENM 126_ QFIHN 131_ GTYIC 136_ DVKNP 141_ PDIVV 146_ QPGHI 151_ RLYVV 156_ EKENL 161_ PVFPV 166_ WVVVG 171_ IVTAV 176_ VLGLT 181_ LLISM 186_ ILAVL 191_ YRRKN 196_ SKRDY 201_ TGCST 206_ SESLS 211_ PVKQA 216_ PRKSP 221_ SDTEG 226_ LVKSL 231_ PSGSH 236_ QGPVI 241_ YAQLD 246_ HSGGH 251_ HSDKI 256_ NKSES 261_VVYAD
1: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility