CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3)
1_MRCPK 6_ SAVTM 11_ RNEEL 16_ LLSNG 21_ TANKM 26_ NGALD 31_ HSDQP 36_ DPDAI 41_ KMFVG 46_ QIPRS 51_ WSEKE 56_ LKELF 61_ EPYGA 66_ VYQIN 71_ VLRDR 76_ SQNPP 81_ QSKGC 86_ CFVTF 91_ YTRKA 96_ ALEAQ 101_ NALHN 106_ IKTLP 111_ GMHHP 116_ IQMKP 121_ ADSEK 126_ SNAVE 131_ DRKLF 136_ IGMVS 141_ KKCNE 146_ NDIRV 151_ MFSPF 156_ GQIEE 161_ CRILR 166_ GPDGL 171_ SRGCA 176_ FVTFS 181_ TRAMA 186_ QNAIK 191_ AMHQS 196_ QTMEG 201_ CSSPI 206_ VVKFA 211_ DTQKD 216_ KEQRR 221_ LQQQL 226_ AQQMQ 231_ QLNTA 236_ TWGNL 241_ TGLGG 246_ LTPQY 251_ LALLQ 256_ QATSS 261_ SNLGA 266_ FSGIQ 271_ QMAGM 276_ NALQL 281_ QNLAT 286_ LAAAA 291_ AAAQT 296_ SATST 301_ NANPL 306_ STTSS 311_ ALGAL 316_ TSPVA 321_ ASTPN 326_ STAGA 331_ AMNSL 336_ TSLGT 341_ LQGLA 346_ GATVG 351_ LNNIN 356_ ALAGM 361_ AALNG 366_ GLGAT 371_ GLTNG 376_ TAGTM 381_ DALTQ 386_ AYSGI 391_ QQYAA 396_ AALPT 401_ LYSQS 406_ LLQQQ 411_ SAAGS 416_ QKEGP 421_ EGANL 426_ FIYHL 431_ PQEFG 436_ DQDIL 441_ QMFMP 446_ FGNVI 451_ SAKVF 456_ IDKQT 461_ NLSKC 466_ FGFVS 471_ YDNPV 476_ SAQAA 481_ IQAMN 486_ GFQIG 491_ MKRLK 496_ VQLKR 501_SKNDS
1: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233)