Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
1_MSGIK 6_ KQKTE 11_ NQQKS 16_ TNVVY 21_ QAHHV 26_ SRNKR 31_ GQVVG 36_ TRGGF 41_ RGCTV 46_ WLTGL 51_ SGAGK 56_ TTISF 61_ ALEEY 66_ LVSHA 71_ IPCYS 76_ LDGDN 81_ VRHGL 86_ NRNLG 91_ FSPGD 96_ REENI 101_ RRIAE 106_ VAKLF 111_ ADAGL 116_ VCITS 121_ FISPF 126_ AKDRE 131_ NARKI 136_ HESAG 141_ LPFFE 146_ IFVDA 151_ PLNIC 156_ ESRDV 161_ KGLYK 166_ RARAG 171_ EIKGF 176_ TGIDS 181_ DYEKP 186_ ETPER 191_ VLKTN 196_ LSTVS 201_ DCVHQ 206_ VVELL 211_ QEQNI 216_ VPYTI 221_ IKDIH 226_ ELFVP 231_ ENKLD 236_ HVRAE 241_ AETLP 246_ SLSIT 251_ KLDLQ 256_ WVQVL 261_ SEGWA 266_ TPLKG 271_ FMREK 276_ EYLQV 281_ MHFDT 286_ LLDDG 291_ VINMS 296_ IPIVL 301_ PVSAE 306_ DKTRL 311_ EGCSK 316_ FVLAH 321_ GGRRV 326_ AILRD 331_ AEFYE 336_ HRKEE 341_ RCSRV 346_ WGTTC 351_ TKHPH 356_ IKMVM 361_ ESGDW 366_ LVGGD 371_ LQVLE 376_ KIRWN 381_ DGLDQ 386_ YRLTP 391_ LELKQ 396_ KCKEM 401_ NADAV 406_ FAFQL 411_ RNPVH 416_ NGHAL 421_ LMQDT 426_ RRRLL 431_ ERGYK 436_ HPVLL 441_ LHPLG 446_ GWTKD 451_ DDVPL 456_ DWRMK 461_ QHAAV 466_ LEEGV 471_ LDPKS 476_ TIVAI 481_ FPSPM 486_ LYAGP 491_ TEVQW 496_ HCRSR 501_ MIAGA 506_ NFYIV 511_ GRDPA 516_ GMPHP 521_ ETKKD 526_ LYEPT 531_ HGGKV 536_ LSMAP 541_ GLTSV 546_ EIIPF 551_ RVAAY 556_ NKAKK 561_ AMDFY 566_ DPARH 571_ NEFDF 576_ ISGTR 581_ MRKLA 586_ REGEN 591_ PPDGF 596_ MAPKA 601_ WKVLT 606_DYYRS
1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). Plays indirectly an important role in skeletogenesis during postnatal growth (PubMed:9771708)