Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
1_MAAAT 6_ GDPGL 11_ SKLQF 16_ APFSS 21_ ALDVG 26_ FWHEL 31_ TQKKL 36_ NEYRL 41_ DEAPK 46_ DIKGY 51_ YYNGD 56_ SAGLP 61_ ARLTL 66_ EFSAF 71_ DMSAP 76_ TPARC 81_ CPAIG 86_ TLYNT 91_ NTLES 96_ FKTAD 101_ KKLLL 106_ EQAAN 111_ EIWES 116_ IKSGT 121_ ALENP 126_ VLLNK 131_ FLLLT 136_ FADLK 141_ KYHFY 146_ YWFCY 151_ PALCL 156_ PESLP 161_ LIQGP 166_ VGLDQ 171_ RFSLK 176_ QIEAL 181_ ECAYD 186_ NLCQT 191_ EGVTA 196_ LPYFL 201_ IKYDE 206_ NMVLV 211_ SLLKH 216_ YSDFF 221_ QGQRT 226_ KITIG 231_ VYDPC 236_ NLAQY 241_ PGWPL 246_ RNFLV 251_ LAAHR 256_ WSSSF 261_ QSVEV 266_ VCFRD 271_ RTMQG 276_ ARDVA 281_ HSIIF 286_ EVKLP 291_ EMAFS 296_ PDCPK 301_ AVGWE 306_ KNQKG 311_ GMGPR 316_ MVNLS 321_ ECMDP 326_ KRLAE 331_ SSVDL 336_ NLKLM 341_ CWRLV 346_ PTLDL 351_ DKVVS 356_ VKCLL 361_ LGAGT 366_ LGCNV 371_ ARTLM 376_ GWGVR 381_ HITFV 386_ DNAKI 391_ SYSNP 396_ VRQPL 401_ YEFED 406_ CLGGG 411_ KPKAL 416_ AAADR 421_ LQKIF 426_ PGVNA 431_ RGFNM 436_ SIPMP 441_ GHPVN 446_ FSSVT 451_ LEQAR 456_ RDVEQ 461_ LEQLI 466_ ESHDV 471_ VFLLM 476_ DTRES 481_ RWLPA 486_ VIAAS 491_ KRKLV 496_ INAAL 501_ GFDTF 506_ VVMRH 511_ GLKKP 516_ KQQGA 521_ GDLCP 526_ NHPVA 531_ SADLL 536_ GSSLF 541_ ANIPG 546_ YKLGC 551_ YFCND 556_ VVAPG 561_ DSTRD 566_ RTLDQ 571_ QCTVS 576_ RPGLA 581_ VIAGA 586_ LAVEL 591_ MVSVL 596_ QHPEG 601_ GYAIA 606_ SSSDD 611_ RMNEP 616_ PTSLG 621_ LVPHQ 626_ IRGFL 631_ SRFDN 636_ VLPVS 641_ LAFDK 646_ CTACS 651_ SKVLD 656_ QYERE 661_ GFNFL 666_ AKVFN 671_ SSHSF 676_ LEDLT 681_ GLTLL 686_ HQETQ 691_ AAEIW 696_DMSDD
1: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (PubMed:34161705). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity)