Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)
1_MAELD 6_ LMAPG 11_ PLPRA 16_ TAQPP 21_ APLSP 26_ DSGSP 31_ SPDSG 36_ SASPV 41_ EEEDV 46_ GSSEK 51_ LGRET 56_ EEQDS 61_ DSAEQ 66_ GDPAG 71_ EGKEV 76_ LCDFC 81_ LDDTR 86_ RVKAV 91_ KSCLT 96_ CMVNY 101_ CEEHL 106_ QPHQV 111_ NIKLQ 116_ SHLLT 121_ EPVKD 126_ HNWRY 131_ CPAHH 136_ SPLSA 141_ FCCPD 146_ QQCIC 151_ QDCCQ 156_ EHSGH 161_ TIVSL 166_ DAARR 171_ DKEAE 176_ LQCTQ 181_ LDLER 186_ KLKLN 191_ ENAIS 196_ RLQAN 201_ QKSVL 206_ VSVSE 211_ VKAVA 216_ EMQFG 221_ ELLAA 226_ VRKAQ 231_ ANVML 236_ FLEEK 241_ EQAAL 246_ SQANG 251_ IKAHL 256_ EYRSA 261_ EMEKS 266_ KQELE 271_ RMAAI 276_ SNTVQ 281_ FLEEY 286_ CKFKN 291_ TEDIT 296_ FPSVY 301_ VGLKD 306_ KLSGI 311_ RKVIT 316_ ESTVH 321_ LIQLL 326_ ENYKK 331_ KLQEF 336_ SKEEE 341_ YDIRT 346_ QVSAV 351_ VQRKY 356_ WTSKP 361_ EPSTR 366_ EQFLQ 371_ YAYDI 376_ TFDPD 381_ TAHKY 386_ LRLQE 391_ ENRKV 396_ TNTTP 401_ WEHPY 406_ PDLPS 411_ RFLHW 416_ RQVLS 421_ QQSLY 426_ LHRYY 431_ FEVEI 436_ FGAGT 441_ YVGLT 446_ CKGID 451_ RKGEE 456_ RNSCI 461_ SGNNF 466_ SWSLQ 471_ WNGKE 476_ FTAWY 481_ SDMET 486_ PLKAG 491_ PFRRL 496_ GVYID 501_ FPGGI 506_ LSFYG 511_ VEYDT 516_ MTLVH 521_ KFACK 526_ FSEPV 531_ YAAFW 536_ LSKKE 541_ NAIRI 546_ VDLGE 551_ EPEKP 556_APSLV
1: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage