Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)
1_MCGNT 6_ MSVPL 11_ LTDAA 16_ TVSGA 21_ ERETA 26_ AVIFL 31_ HGLGD 36_ TGHSW 41_ ADALS 46_ TIRLP 51_ HVKYI 56_ CPHAP 61_ RIPVT 66_ LNMKM 71_ VMPSW 76_ FDLMG 81_ LSPDA 86_ PEDEA 91_ GIKKA 96_ AENIK 101_ ALIEH 106_ EMKNG 111_ IPANR 116_ IVLGG 121_ FSQGG 126_ ALSLY 131_ TALTC 136_ PHPLA 141_ GIVAL 146_ SCWLP 151_ LHRAF 156_ PQAAN 161_ GSAKD 166_ LAILQ 171_ CHGEL 176_ DPMVP 181_ VRFGA 186_ LTAEK 191_ LRSVV 196_ TPARV 201_ QFKTY 206_ PGVMH 211_ SSCPQ 216_ EMAAV 221_ KEFLE 226_KLLPP
1: Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951)