Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)
1_MDPNT 6_ IIEAL 11_ RGTMD 16_ PALRE 21_ AAERQ 26_ LNEAH 31_ KSLNF 36_ VSTLL 41_ QITMS 46_ EQLDL 51_ PVRQA 56_ GVIYL 61_ KNMIT 66_ QYWPD 71_ RETAP 76_ GDISP 81_ YTIPE 86_ EDRHC 91_ IRENI 96_ VEAII 101_ HSPEL 106_ IRVQL 111_ TTCIH 116_ HIIKH 121_ DYPSR 126_ WTAIV 131_ DKIGF 136_ YLQSD 141_ NSACW 146_ LGILL 151_ CLYQL 156_ VKNYE 161_ YKKPE 166_ ERSPL 171_ VAAMQ 176_ HFLPV 181_ LKDRF 186_ IQLLS 191_ DQSDQ 196_ SVLIQ 201_ KQIFK 206_ IFYAL 211_ VQYTL 216_ PLELI 221_ NQQNL 226_ TEWIE 231_ ILKTV 236_ VNRDV 241_ PNETL 246_ QVEED 251_ DRPEL 256_ PWWKC 261_ KKWAL 266_ HILAR 271_ LFERY 276_ GSPGN 281_ VSKEY 286_ NEFAE 291_ VFLKA 296_ FAVGV 301_ QQVLL 306_ KVLYQ 311_ YKEKQ 316_ YMAPR 321_ VLQQT 326_ LNYIN 331_ QGVSH 336_ ALTWK 341_ NLKPH 346_ IQGII 351_ QDVIF 356_ PLMCY 361_ TDADE 366_ ELWQE 371_ DPYEY 376_ IRMKF 381_ DVFED 386_ FISPT 391_ TAAQT 396_ LLFTA 401_ CSKRK 406_ EVLQK 411_ TMGFC 416_ YQILT 421_ EPNAD 426_ PRKKD 431_ GALHM 436_ IGSLA 441_ EILLK 446_ KKIYK 451_ DQMEY 456_ MLQNH 461_ VFPLF 466_ SSELG 471_ YMRAR 476_ ACWVL 481_ HYFCE 486_ VKFKS 491_ DQNLQ 496_ TALEL 501_ TRRCL 506_ IDDRE 511_ MPVKV 516_ EAAIA 521_ LQVLI 526_ SNQEK 531_ AKEYI 536_ TPFIR 541_ PVMQA 546_ LLHII 551_ RETEN 556_ DDLTN 561_ VIQKM 566_ ICEYS 571_ EEVTP 576_ IAVEM 581_ TQHLA 586_ MTFNQ 591_ VIQTG 596_ PDEEG 601_ SDDKA 606_ VTAMG 611_ ILNTI 616_ DTLLS 621_ VVEDH 626_ KEITQ 631_ QLEGI 636_ CLQVI 641_ GTVLQ 646_ QHVLE 651_ FYEEI 656_ FSLAH 661_ SLTCQ 666_ QVSPQ 671_ MWQLL 676_ PLVFE 681_ VFQQD 686_ GFDYF 691_ TDMMP 696_ LLHNY 701_ VTVDT 706_ DTLLS 711_ DTKYL 716_ EMIYS 721_ MCKKV 726_ LTGVA 731_ GEDAE 736_ CHAAK 741_ LLEVI 746_ ILQCK 751_ GRGID 756_ QCIPL 761_ FVEAA 766_ LERLT 771_ REVKT 776_ SELRT 781_ MCLQV 786_ AIAAL 791_ YYNPH 796_ LLLNT 801_ LENLR 806_ FPNNV 811_ EPVTN 816_ HFITQ 821_ WLNDV 826_ DCFLG 831_ LHDRK 836_ MCVLG 841_ LCALI 846_ DMEQI 851_ PQVLN 856_ QVSGQ 861_ ILPAF 866_ ILLFN 871_ GLKRA 876_ YACHA 881_ EHEND 886_ SDDDD 891_ EAEDD 896_ DETEE 901_ LGSDE 906_ DDIDE 911_ DGQEY 916_ LEILA 921_ KQAGE 926_ DGDDE 931_ DWEED 936_ DAEET 941_ ALEGY 946_ STIID 951_ DEDNP 956_ VDEYQ 961_ IFKAI 966_ FQTIQ 971_ NRNPV 976_ WYQAL 981_ THGLN 986_ EEQRK 991_ QLQDI 996_ ATLAD 1001_ QRRAA 1006_ HESKM 1011_ IEKHG 1016_ GYKFS 1021_ APVVP 1026_ SSFNF 1031_GGPAP
1: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (By similarity). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (By similarity). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (By similarity). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones
2: (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev