CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein)
1_MRWFL 6_ PWTLA 11_ AVTAA 16_ AASTV 21_ LATAL 26_ SPAPT 31_ TMDFT 36_ PAPLE 41_ DTSSR 46_ PQFCK 51_ WPCEC 56_ PPSPP 61_ RCPLG 66_ VSLIT 71_ DGCEC 76_ CKMCA 81_ QQLGD 86_ NCTEA 91_ AICDP 96_ HRGLY 101_ CDYSG 106_ DRPRY 111_ AIGVC 116_ AQVVG 121_ VGCVL 126_ DGVRY 131_ NNGQS 136_ FQPNC 141_ KYNCT 146_ CIDGA 151_ VGCTP 156_ LCLRV 161_ RPPRL 166_ WCPHP 171_ RRVSI 176_ PGHCC 181_ EQWVC 186_ EDDAK 191_ RPRKT 196_ APRDT 201_ GAFDA 206_ VGEVE 211_ AWHRN 216_ CIAYT 221_ SPWSP 226_ CSTSC 231_ GLGVS 236_ TRISN 241_ VNAQC 246_ WPEQE 251_ SRLCN 256_ LRPCD 261_ VDIHT 266_ LIKAG 271_ KKCLA 276_ VYQPE 281_ ASMNF 286_ TLAGC 291_ ISTRS 296_ YQPKY 301_ CGVCM 306_ DNRCC 311_ IPYKS 316_ KTIDV 321_ SFQCP 326_ DGLGF 331_ SRQVL 336_ WINAC 341_ FCNLS 346_ CRNPN 351_ DIFAD 356_ LESYP 361_DFSEI
1: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan