Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11)
1_MVLAA 6_ PLLLG 11_ FLLLA 16_ LELRP 21_ RGEAA 26_ EGPAA 31_ AAAAA 36_ AAAAA 41_ AGVGG 46_ ERSSR 51_ PAPSV 56_ APEPD 61_ GCPVC 66_ VWRQH 71_ SRELR 76_ LESIK 81_ SQILS 86_ KLRLK 91_ EAPNI 96_ SREVV 101_ KQLLP 106_ KAPPL 111_ QQILD 116_ LHDFQ 121_ GDALQ 126_ PEDFL 131_ EEDEY 136_ HATTE 141_ TVISM 146_ AQETD 151_ PAVQT 156_ DGSPL 161_ CCHFH 166_ FSPKV 171_ MFTKV 176_ LKAQL 181_ WVYLR 186_ PVPRP 191_ ATVYL 196_ QILRL 201_ KPLTG 206_ EGTAG 211_ GGGGG 216_ RRHIR 221_ IRSLK 226_ IELHS 231_ RSGHW 236_ QSIDF 241_ KQVLH 246_ SWFRQ 251_ PQSNW 256_ GIEIN 261_ AFDPS 266_ GTDLA 271_ VTSLG 276_ PGAEG 281_ LHPFM 286_ ELRVL 291_ ENTKR 296_ SRRNL 301_ GLDCD 306_ EHSSE 311_ SRCCR 316_ YPLTV 321_ DFEAF 326_ GWDWI 331_ IAPKR 336_ YKANY 341_ CSGQC 346_ EYMFM 351_ QKYPH 356_ THLVQ 361_ QANPR 366_ GSAGP 371_ CCTPT 376_ KMSPI 381_ NMLYF 386_ NDKQQ 391_ IIYGK 396_ IPGMV 401_VDRCG
1: Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634)