Pre-mRNA-splicing factor SLU7 (hSlu7)
1_MSATV 6_ VDAVN 11_ AAPLS 16_ GSKEM 21_ SLEEP 26_ KKMTR 31_ EDWRK 36_ KKELE 41_ EQRKL 46_ GNAPA 51_ EVDEE 56_ GKDIN 61_ PHIPQ 66_ YISSV 71_ PWYID 76_ PSKRP 81_ TLKHQ 86_ RPQPE 91_ KQKQF 96_ SSSGE 101_ WYKRG 106_ VKENS 111_ IITKY 116_ RKGAC 121_ ENCGA 126_ MTHKK 131_ KDCFE 136_ RPRRV 141_ GAKFT 146_ GTNIA 151_ PDEHV 156_ QPQLM 161_ FDYDG 166_ KRDRW 171_ NGYNP 176_ EEHMK 181_ IVEEY 186_ AKVDL 191_ AKRTL 196_ KAQKL 201_ QEELA 206_ SGKLV 211_ EQANS 216_ PKHQW 221_ GEEEP 226_ NSQME 231_ KDHNS 236_ EDEDE 241_ DKYAD 246_ DIDMP 251_ GQNFD 256_ SKRRI 261_ TVRNL 266_ RIRED 271_ IAKYL 276_ RNLDP 281_ NSAYY 286_ DPKTR 291_ AMREN 296_ PYANA 301_ GKNPD 306_ EVSYA 311_ GDNFV 316_ RYTGD 321_ TISMA 326_ QTQLF 331_ AWEAY 336_ DKGSE 341_ VHLQA 346_ DPTKL 351_ ELLYK 356_ SFKVK 361_ KEDFK 366_ EQQKE 371_ SILEK 376_ YGGQE 381_ HLDAP 386_ PAELL 391_ LAQTE 396_ DYVEY 401_ SRHGT 406_ VIKGQ 411_ ERAVA 416_ CSKYE 421_ EDVKI 426_ HNHTH 431_ IWGSY 436_ WKEGR 441_ WGYKC 446_ CHSFF 451_ KYSYC 456_ TGEAG 461_ KEIVN 466_ SEECI 471_ INEIT 476_ GEESV 481_ KKPQT 486_ LMELH 491_ QEKLK 496_ EEKKK 501_ KKKKK 506_ KKHRK 511_ SSSDS 516_ DDEEK 521_ KHEKL 526_ KKALN 531_ AEEAR 536_ LLHVK 541_ ETMQI 546_ DERKR 551_ PYNSM 556_ YETRE 561_ PTEEE 566_ MEAYR 571_ MKRQR 576_ PDDPM 581_ASFLG
1: Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation