Bone morphogenetic protein 10 (BMP-10)
1_MGSLV 6_ LTLCA 11_ LFCLA 16_ AYLVS 21_ GSPIM 26_ NLEQS 31_ PLEED 36_ MSLFG 41_ DVFSE 46_ QDGVD 51_ FNTLL 56_ QSMKD 61_ EFLKT 66_ LNLSD 71_ IPTQD 76_ SAKVD 81_ PPEYM 86_ LELYN 91_ KFATD 96_ RTSMP 101_ SANII 106_ RSFKN 111_ EDLFS 116_ QPVSF 121_ NGLRK 126_ YPLLF 131_ NVSIP 136_ HHEEV 141_ IMAEL 146_ RLYTL 151_ VQRDR 156_ MIYDG 161_ VDRKI 166_ TIFEV 171_ LESKG 176_ DNEGE 181_ RNMLV 186_ LVSGE 191_ IYGTN 196_ SEWET 201_ FDVTD 206_ AIRRW 211_ QKSGS 216_ STHQL 221_ EVHIE 226_ SKHDE 231_ AEDAS 236_ SGRLE 241_ IDTSA 246_ QNKHN 251_ PLLIV 256_ FSDDQ 261_ SSDKE 266_ RKEEL 271_ NEMIS 276_ HEQLP 281_ ELDNL 286_ GLDSF 291_ SSGPG 296_ EEALL 301_ QMRSN 306_ IIYDS 311_ TARIR 316_ RNAKG 321_ NYCKR 326_ TPLYI 331_ DFKEI 336_ GWDSW 341_ IIAPP 346_ GYEAY 351_ ECRGV 356_ CNYPL 361_ AEHLT 366_ PTKHA 371_ IIQAL 376_ VHLKN 381_ SQKAS 386_ KACCV 391_ PTKLE 396_ PISIL 401_ YLDKG 406_ VVTYK 411_ FKYEG 416_MAVSE
1: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines