Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)
1_MKVGW 6_ PGESC 11_ WQVGL 16_ AVEDS 21_ PALGA 26_ PRVGA 31_ LPDVV 36_ PEGTL 41_ LNMVL 46_ RRMHR 51_ PRSCS 56_ YQLLL 61_ EHQRP 66_ SCIQG 71_ LRWTP 76_ LTNSE 81_ ESLDF 86_ SESLE 91_ QASTE 96_ RVLRA 101_ GRQLH 106_ RHLLA 111_ TCPNL 116_ IRDRK 121_ YHLRL 126_ YRQCC 131_ SGREL 136_ VDGIL 141_ ALGLG 146_ VHSRS 151_ QVVGI 156_ CQVLL 161_ DEGAL 166_ CHVKH 171_ DWAFQ 176_ DRDAQ 181_ FYRFP 186_ GPEPE 191_ PVRTH 196_ EMEEE 201_ LAEAV 206_ ALLSQ 211_ RGPDA 216_ LLTVA 221_ LRKPP 226_ GQRTD 231_ EELDL 236_ IFEEL 241_ LHIKA 246_ VAHLS 251_ NSVKR 256_ ELAAV 261_ LLFEP 266_ HSKAG 271_ TVLFS 276_ QGDKG 281_ TSWYI 286_ IWKGS 291_ VNVVT 296_ HGKGL 301_ VTTLH 306_ EGDDF 311_ GQLAL 316_ VNDAP 321_ RAATI 326_ ILRED 331_ NCHFL 336_ RVDKQ 341_ DFNRI 346_ IKDVE 351_ AKTMR 356_ LEEHG 361_ KVVLV 366_ LERAS 371_ QGAGP 376_ SRPPT 381_ PGRNR 386_ YTVMS 391_ GTPEK 396_ ILELL 401_ LEAMG 406_ PDSSA 411_ HDPTE 416_ TFLSD 421_ FLLTH 426_ RVFMP 431_ SAQLC 436_ AALLH 441_ HFHVE 446_ PAGGS 451_ EQERS 456_ TYVCN 461_ KRQQI 466_ LRLVS 471_ QWVAL 476_ YGSML 481_ HTDPV 486_ ATSFL 491_ QKLSD 496_ LVGRD 501_ TRLSN 506_ LLREQ 511_ WPERR 516_ RCHRL 521_ ENGCG 526_ NASPQ 531_ MKARN 536_ LPVWL 541_ PNQDE 546_ PLPGS 551_ SCAIQ 556_ VGDKV 561_ PYDIC 566_ RPDHS 571_ VLTLQ 576_ LPVTA 581_ SVREV 586_ MAALA 591_ QEDGW 596_ TKGQV 601_ LVKVN 606_ SAGDA 611_ IGLQP 616_ DARGV 621_ ATSLG 626_ LNERL 631_ FVVNP 636_ QEVHE 641_ LIPHP 646_ DQLGP 651_ TVGSA 656_ EGLDL 661_ VSAKD 666_ LAGQL 671_ TDHDW 676_ SLFNS 681_ IHQVE 686_ LIHYV 691_ LGPQH 696_ LRDVT 701_ TANLE 706_ RFMRR 711_ FNELQ 716_ YWVAT 721_ ELCLC 726_ PVPGP 731_ RAQLL 736_ RKFIK 741_ LAAHL 746_ KEQKN 751_ LNSFF 756_ AVMFG 761_ LSNSA 766_ ISRLA 771_ HTWER 776_ LPHKV 781_ RKLYS 786_ ALERL 791_ LDPSW 796_ NHRVY 801_ RLALA 806_ KLSPP 811_ VIPFM 816_ PLLLK 821_ DMTFI 826_ HEGNH 831_ TLVEN 836_ LINFE 841_ KMRMM 846_ ARAAR 851_ MLHHC 856_ RSHNP 861_ VPLSP 866_ LRSRV 871_ SHLHE 876_ DSQVA 881_ RISTC 886_ SEQSL 891_ STRSP 896_ ASTWA 901_ YVQQL 906_ KVIDN 911_ QRELS 916_RLSRE
1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin