Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2)
1_MLLDA 6_ GPQFP 11_ AIGVG 16_ SFARH 21_ HHHSA 26_ AAAAA 31_ AAAEM 36_ QDREL 41_ SLAAA 46_ QNGFV 51_ DSAAA 56_ HMGAF 61_ KLNPG 66_ AHELS 71_ PGQSS 76_ AFTSQ 81_ GPGAY 86_ PGSAA 91_ AAAAA 96_ AALGP 101_ HAAHV 106_ GSYSG 111_ PPFNS 116_ TRDFL 121_ FRSRG 126_ FGDSA 131_ PGGGQ 136_ HGLFG 141_ PGAGG 146_ LHHAH 151_ SDAQG 156_ HLLFP 161_ GLPEQ 166_ HGPHG 171_ SQNVL 176_ NGQMR 181_ LGLPG 186_ EVFGR 191_ SEQYR 196_ QVASP 201_ RTDPY 206_ SAAQL 211_ HNQYG 216_ PMNMN 221_ MGMNM 226_ AAAAA 231_ HHHHH 236_ HHHHP 241_ GAFFR 246_ YMRQQ 251_ CIKQE 256_ LICKW 261_ IDPEQ 266_ LSNPK 271_ KSCNK 276_ TFSTM 281_ HELVT 286_ HVSVE 291_ HVGGP 296_ EQSNH 301_ VCFWE 306_ ECPRE 311_ GKPFK 316_ AKYKL 321_ VNHIR 326_ VHTGE 331_ KPFPC 336_ PFPGC 341_ GKVFA 346_ RSENL 351_ KIHKR 356_ THTGE 361_ KPFQC 366_ EFEGC 371_ DRRFA 376_ NSSDR 381_ KKHMH 386_ VHTSD 391_ KPYLC 396_ KMCDK 401_ SYTHP 406_ SSLRK 411_ HMKVH 416_ ESSPQ 421_ GSESS 426_ PAASS 431_ GYESS 436_ TPPGL 441_ VSPSA 446_ EPQSS 451_ SNLSP 456_ AAAAA 461_ AAAAA 466_ AAAAA 471_ VSAVH 476_ RGGGS 481_ GSGGA 486_ GGGSG 491_ GGSGS 496_ GGGGG 501_ GAGGG 506_ GGGSS 511_ GGGSG 516_ TAGGH 521_ SGLSS 526_NFNEW
1: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos