Supervillin (Archvillin) (p205/p250)
1_MKRKE 6_ RIARR 11_ LEGIE 16_ NDTQP 21_ ILLQS 26_ CTGLV 31_ THRLL 36_ EEDTP 41_ RYMRA 46_ SDPAS 51_ PHIGR 56_ SNEEE 61_ ETSDS 66_ SLEKQ 71_ TRSKY 76_ CTETS 81_ GVHGD 86_ SPYGS 91_ GTMDT 96_ HSLES 101_ KAERI 106_ ARYKA 111_ ERRRQ 116_ LAEKY 121_ GLTLD 126_ PEADS 131_ EYLSR 136_ YTKSR 141_ KEPDA 146_ VEKRG 151_ GKSDK 156_ QEESS 161_ RDASS 166_ LYPGT 171_ ETMGL 176_ RTCAG 181_ ESKDY 186_ ALHVG 191_ DGSSD 196_ PEVLL 201_ NIENQ 206_ RRGQE 211_ LSATR 216_ QAHDL 221_ SPAAE 226_ SSSTF 231_ SFSGR 236_ DSSFT 241_ EVPRS 246_ PKHAH 251_ SSSLQ 256_ QAASR 261_ SPSFG 266_ DPQLS 271_ PEARP 276_ STGKP 281_ KHEWF 286_ LQKDS 291_ EGDTP 296_ SLINW 301_ PSRVK 306_ VREKL 311_ VKEES 316_ ARNSP 321_ ELASE 326_ SVTQR 331_ RHQPA 336_ PVHYV 341_ SFQSE 346_ HSAFD 351_ RVPSK 356_ AAGST 361_ RQPIR 366_ GYVQP 371_ ADTGH 376_ TAKLV 381_ TPETP 386_ ENASE 391_ CSWVA 396_ SATQN 401_ VPKPP 406_ SLTVL 411_ EGDGR 416_ DSPVL 421_ HVCES 426_ KAEEE 431_ EGEGE 436_ GEEKE 441_ EDVCF 446_ TEALE 451_ QSKKT 456_ LLALE 461_ GDGLV 466_ RSPED 471_ PSRNE 476_ DFGKP 481_ AVSTV 486_ TLEHQ 491_ KELEN 496_ VAQPP 501_ QAPHQ 506_ PTERT 511_ GRSEM 516_ VLYIQ 521_ SEPVS 526_ QDAKP 531_ TGHNR 536_ EASKK 541_ RKVRT 546_ RSLSD 551_ FTGPP 556_ QLQAL 561_ KYKDP 566_ ASRRE 571_ LELPS 576_ SKTEG 581_ PYGEI 586_ SMLDT 591_ KVSVA 596_ QLRSA 601_ FLASA 606_ NACRR 611_ PELKS 616_ RVERS 621_ AEGPG 626_ LPTGV 631_ ERERG 636_ SRKPR 641_ RYFSP 646_ GESRK 651_ TSERF 656_ RTQPI 661_ TSAER 666_ KESDR 671_ CTSHS 676_ ETPTV 681_ DDEEK 686_ VDERA 691_ KLSVA 696_ AKRLL 701_ FREME 706_ KSFDE 711_ QNVPK 716_ RRSRN 721_ TAVEQ 726_ RLRRL 731_ QDRSL 736_ TQPIT 741_ TEEVV 746_ IAATE 751_ PIPAS 756_ CSGGT 761_ HPVMA 766_ RLPSP 771_ TVARS 776_ AVQPA 781_ RLQAS 786_ AHQKA 791_ LAKDQ 796_ TNEGK 801_ ELAEQ 806_ GEPDS 811_ STLSL 816_ AEKLA 821_ LFNKL 826_ SQPVS 831_ KAIST 836_ RNRID 841_ TRQRR 846_ MNARY 851_ QTQPV 856_ TLGEV 861_ EQVQS 866_ GKLIP 871_ FSPAV 876_ NTSVS 881_ TVAST 886_ VAPMY 891_ AGDLR 896_ TKPPL 901_ DHNAS 906_ ATDYK 911_ FSSSI 916_ ENSDS 921_ PVRSI 926_ LKSQA 931_ WQPLV 936_ EGSEN 941_ KGMLR 946_ EYGET 951_ ESKRA 956_ LTGRD 961_ SGMEK 966_ YGSFE 971_ EAEAS 976_ YPILN 981_ RAREG 986_ DSHKE 991_ SKYAV 996_ PRRGS 1001_ LERAN 1006_ PPITH 1011_ LGDEP 1016_ KEFSM 1021_ AKMNA 1026_ QGNLD 1031_ LRDRL 1036_ PFEEK 1041_ VEVEN 1046_ VMKRK 1051_ FSLRA 1056_ AEFGE 1061_ PTSEQ 1066_ TGTAA 1071_ GKTIA 1076_ QTTAP 1081_ VSWKP 1086_ QDSSE 1091_ QPQEK 1096_ LCKNP 1101_ CAMFA 1106_ AGEIK 1111_ TPTGE 1116_ GLLDS 1121_ PSKTM 1126_ SIKER 1131_ LALLK 1136_ KSGEE 1141_ DWRNR 1146_ LSRRQ 1151_ EGGKA 1156_ PASSL 1161_ HTQEA 1166_ GRSLI 1171_ KKRVT 1176_ ESRES 1181_ QMTIE 1186_ ERKQL 1191_ ITVRE 1196_ EAWKT 1201_ RGRGA 1206_ ANDST 1211_ QFTVA 1216_ GRMVK 1221_ KGLAS 1226_ PTAIT 1231_ PVASP 1236_ ICGKT 1241_ RGTTP 1246_ VSKPL 1251_ EDIEA 1256_ RPDMQ 1261_ LESDL 1266_ KLDRL 1271_ ETFLR 1276_ RLNNK 1281_ VGGMH 1286_ ETVLT 1291_ VTGKS 1296_ VKEVM 1301_ KPDDD 1306_ ETFAK 1311_ FYRSV 1316_ DYNMP 1321_ RSPVE 1326_ MDEDF 1331_ DVIFD 1336_ PYAPK 1341_ LTSSV 1346_ AEHKR 1351_ AVRPK 1356_ RRVQA 1361_ SKNPL 1366_ KMLAA 1371_ REDLL 1376_ QEYTE 1381_ QRLNV 1386_ AFMES 1391_ KRMKV 1396_ EKMSS 1401_ NSNFS 1406_ EVTLA 1411_ GLASK 1416_ ENFSN 1421_ VSLRS 1426_ VNLTE 1431_ QNSNN 1436_ SAVPY 1441_ KRLML 1446_ LQIKG 1451_ RRHVQ 1456_ TRLVE 1461_ PRASA 1466_ LNSGD 1471_ CFLLL 1476_ SPHCC 1481_ FLWVG 1486_ EFANV 1491_ IEKAK 1496_ ASELA 1501_ TLIQT 1506_ KRELG 1511_ CRATY 1516_ IQTIE 1521_ EGINT 1526_ HTHAA 1531_ KDFWK 1536_ LLGGQ 1541_ TSYQS 1546_ AGDPK 1551_ EDELY 1556_ EAAII 1561_ ETNCI 1566_ YRLMD 1571_ DKLVP 1576_ DDDYW 1581_ GKIPK 1586_ CSLLQ 1591_ PKEVL 1596_ VFDFG 1601_ SEVYV 1606_ WHGKE 1611_ VTLAQ 1616_ RKIAF 1621_ QLAKH 1626_ LWNGT 1631_ FDYEN 1636_ CDINP 1641_ LDPGE 1646_ CNPLI 1651_ PRKGQ 1656_ GRPDW 1661_ AIFGR 1666_ LTEHN 1671_ ETILF 1676_ KEKFL 1681_ DWTEL 1686_ KRSNE 1691_ KNPGE 1696_ LAQHK 1701_ EDPRT 1706_ DVKAY 1711_ DVTRM 1716_ VSMPQ 1721_ TTAGT 1726_ ILDGV 1731_ NVGRG 1736_ YGLVE 1741_ GHDRR 1746_ QFEIT 1751_ SVSVD 1756_ VWHIL 1761_ EFDYS 1766_ RLPKQ 1771_ SIGQF 1776_ HEGDA 1781_ YVVKW 1786_ KFMVS 1791_ TAVGS 1796_ RQKGE 1801_ HSVRA 1806_ AGKEK 1811_ CVYFF 1816_ WQGRH 1821_ STVSE 1826_ KGTSA 1831_ LMTVE 1836_ LDEER 1841_ GAQVQ 1846_ VLQGK 1851_ EPPCF 1856_ LQCFQ 1861_ GGMVV 1866_ HSGRR 1871_ EEEEE 1876_ NVQSE 1881_ WRLYC 1886_ VRGEV 1891_ PVEGN 1896_ LLEVA 1901_ CHCSS 1906_ LRSRT 1911_ SMVVL 1916_ NVNKA 1921_ LIYLW 1926_ HGCKA 1931_ QAHTK 1936_ EVGRT 1941_ AANKI 1946_ KEQCP 1951_ LEAGL 1956_ HSSSK 1961_ VTIHE 1966_ CDEGS 1971_ EPLGF 1976_ WDALG 1981_ RRDRK 1986_ AYDCM 1991_ LQDPG 1996_ SFNFA 2001_ PRLFI 2006_ LSSSS 2011_ GDFAA 2016_ TEFVY 2021_ PARAP 2026_ SVVSS 2031_ MPFLQ 2036_ EDLYS 2041_ APQPA 2046_ LFLVD 2051_ NHHEV 2056_ YLWQG 2061_ WWPIE 2066_ NKITG 2071_ SARIR 2076_ WASDR 2081_ KSAME 2086_ TVLQY 2091_ CKGKN 2096_ LKKPA 2101_ PKSYL 2106_ IHAGL 2111_ EPLTF 2116_ TNMFP 2121_ SWEHR 2126_ EDIAE 2131_ ITEMD 2136_ TEVSN 2141_ QITLV 2146_ EDVLA 2151_ KLCKT 2156_ IYPLA 2161_ DLLAR 2166_ PLPEG 2171_ VDPLK 2176_ LEIYL 2181_ TDEDF 2186_ EFALD 2191_ MTRDE 2196_ YNALP 2201_ AWKQV 2206_NLKKA
1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420)
2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity)