Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)
1_MAKWG 6_ EGDPR 11_ WIVEE 16_ RADAT 21_ NVNNW 26_ HWTER 31_ DASNW 36_ STDKL 41_ KTLFL 46_ AVQVQ 51_ NEEGK 56_ CEVTE 61_ VSKLD 66_ GEASI 71_ NNRKG 76_ KLIFF 81_ YEWSV 86_ KLNWT 91_ GTSKS 96_ GVQYK 101_ GHVEI 106_ PNLSD 111_ ENSVD 116_ EVEIS 121_ VSLAK 126_ DEPDT 131_ NLVAL 136_ MKEEG 141_ VKLLR 146_ EAMGI 151_ YISTL 156_ KTEFT 161_ QGMIL 166_ PTMNG 171_ ESVDP 176_ VGQPA 181_ LKTEE 186_ RKAKP 191_ APSKT 196_ QARPV 201_ GVKIP 206_ TCKIT 211_ LKETF 216_ LTSPE 221_ ELYRV 226_ FTTQE 231_ LVQAF 236_ THAPA 241_ TLEAD 246_ RGGKF 251_ HMVDG 256_ NVSGE 261_ FTDLV 266_ PEKHI 271_ VMKWR 276_ FKSWP 281_ EGHFA 286_ TITLT 291_ FIDKN 296_ GETEL 301_ CMEGR 306_ GIPAP 311_ EEERT 316_ RQGWQ 321_ RYYFE 326_ GIKQT 331_FGYGA
1: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155)