A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)
1_MDPPA 6_ GAARR 11_ LLCPA 16_ LLLLL 21_ LLLPP 26_ PLLPP 31_ PPPPA 36_ NARLA 41_ AAADP 46_ PGGPL 51_ GHGAE 56_ RILAV 61_ PVRTD 66_ AQGRL 71_ VSHVV 76_ SAATS 81_ RAGVR 86_ ARRAA 91_ PVRTP 96_ SFPGG 101_ NEEEP 106_ GSHLF 111_ YNVTV 116_ FGRDL 121_ HLRLR 126_ PNARL 131_ VAPGA 136_ TMEWQ 141_ GEKGT 146_ TRVEP 151_ LLGSC 156_ LYVGD 161_ VAGLA 166_ EASSV 171_ ALSNC 176_ DGLAG 181_ LIRME 186_ EEEFF 191_ IEPLE 196_ KGLAA 201_ QEAEQ 206_ GRVHV 211_ VYRRP 216_ PTSPP 221_ LGGPQ 226_ ALDTG 231_ ASLDS 236_ LDSLS 241_ RALGV 246_ LEEHA 251_ NSSRR 256_ RARRH 261_ AADDD 266_ YNIEV 271_ LLGVD 276_ DSVVQ 281_ FHGKE 286_ HVQKY 291_ LLTLM 296_ NIVNE 301_ IYHDE 306_ SLGAH 311_ INVVL 316_ VRIIL 321_ LSYGK 326_ SMSLI 331_ EIGNP 336_ SQSLE 341_ NVCRW 346_ AYLQQ 351_ KPDTG 356_ HDEYH 361_ DHAIF 366_ LTRQD 371_ FGPSG 376_ MQGYA 381_ PVTGM 386_ CHPVR 391_ SCTLN 396_ HEDGF 401_ SSAFV 406_ VAHET 411_ GHVLG 416_ MEHDG 421_ QGNRC 426_ GDEVR 431_ LGSIM 436_ APLVQ 441_ AAFHR 446_ FHWSR 451_ CSQQE 456_ LSRYL 461_ HSYDC 466_ LLDDP 471_ FAHDW 476_ PALPQ 481_ LPGLH 486_ YSMNE 491_ QCRFD 496_ FGLGY 501_ MMCTA 506_ FRTFD 511_ PCKQL 516_ WCSHP 521_ DNPYF 526_ CKTKK 531_ GPPLD 536_ GTMCA 541_ PGKHC 546_ FKGHC 551_ IWLTP 556_ DILKR 561_ DGSWG 566_ AWSPF 571_ GSCSR 576_ TCGTG 581_ VKFRT 586_ RQCDN 591_ PHPAN 596_ GGRTC 601_ SGLAY 606_ DFQLC 611_ SRQDC 616_ PDSLA 621_ DFREE 626_ QCRQW 631_ DLYFE 636_ HGDAQ 641_ HHWLP 646_ HEHRD 651_ AKERC 656_ HLYCE 661_ SRETG 666_ EVVSM 671_ KRMVH 676_ DGTRC 681_ SYKDA 686_ FSLCV 691_ RGDCR 696_ KVGCD 701_ GVIGS 706_ SKQED 711_ KCGVC 716_ GGDNS 721_ HCKVV 726_ KGTFT 731_ RSPKK 736_ HGYIK 741_ MFEIP 746_ AGARH 751_ LLIQE 756_ VDATS 761_ HHLAV 766_ KNLET 771_ GKFIL 776_ NEEND 781_ VDASS 786_ KTFIA 791_ MGVEW 796_ EYRDE 801_ DGRET 806_ LQTMG 811_ PLHGT 816_ ITVLV 821_ IPVGD 826_ TRVSL 831_ TYKYM 836_ IHEDS 841_ LNVDD 846_ NNVLE 851_ EDSVV 856_ YEWAL 861_ KKWSP 866_ CSKPC 871_ GGGSQ 876_ FTKYG 881_ CRRRL 886_ DHKMV 891_ HRGFC 896_ AALSK 901_ PKAIR 906_ RACNP 911_ QECSQ 916_ PVWVT 921_ GEWEP 926_ CSQTC 931_ GRTGM 936_ QVRSV 941_ RCIQP 946_ LHDNT 951_ TRSVH 956_ AKHCN 961_ DARPE 966_ SRRAC 971_ SRELC 976_ PGRWR 981_ AGPWS 986_ QCSVT 991_ CGNGT 996_ QERPV 1001_ LCRTA 1006_ DDSFG 1011_ ICQEE 1016_ RPETA 1021_ RTCRL 1026_ GPCPR 1031_ NISDP 1036_ SKKSY 1041_ VVQWL 1046_ SRPDP 1051_ DSPIR 1056_ KISSK 1061_ GHCQG 1066_ DKSIF 1071_ CRMEV 1076_ LSRYC 1081_ SIPGY 1086_ NKLCC 1091_ KSCNL 1096_ YNNLT 1101_ NVEGR 1106_ IEPPP 1111_ GKHND 1116_ IDVFM 1121_ PTLPV 1126_ PTVAM 1131_ EVRPS 1136_ PSTPL 1141_ EVPLN 1146_ ASSTN 1151_ ATEDH 1156_ PETNA 1161_ VDEPY 1166_ KIHGL 1171_ EDEVQ 1176_ PPNLI 1181_ PRRPS 1186_ PYEKT 1191_ RNQRI 1196_ QELID 1201_ EMRKK 1206_EMLGK
1: Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (PubMed:31152061)