Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)
1_MEIIR 6_ SNFKS 11_ NLHKV 16_ YQAIE 21_ EADFF 26_ AIDGE 31_ FSGIS 36_ DGPSV 41_ SALTN 46_ GFDTP 51_ EERYQ 56_ KLKKH 61_ SMDFL 66_ LFQFG 71_ LCTFK 76_ YDYTD 81_ SKYIT 86_ KSFNF 91_ YVFPK 96_ PFNRS 101_ SPDVK 106_ FVCQS 111_ SSIDF 116_ LASQG 121_ FDFNK 126_ VFRNG 131_ IPYLN 136_ QEEER 141_ QLREQ 146_ YDEKR 151_ SQANG 156_ AGALS 161_ YVSPN 166_ TSKCP 171_ VTIPE 176_ DQKKF 181_ IDQVV 186_ EKIED 191_ LLQSE 196_ ENKNL 201_ DLEPC 206_ TGFQR 211_ KLIYQ 216_ TLSWK 221_ YPKGI 226_ HVETL 231_ ETEKK 236_ ERYIV 241_ ISKVD 246_ EEERK 251_ RREQQ 256_ KHAKE 261_ QEELN 266_ DAVGF 271_ SRVIH 276_ AIANS 281_ GKLVI 286_ GHNML 291_ LDVMH 296_ TVHQF 301_ YCPLP 306_ ADLSE 311_ FKEMT 316_ TCVFP 321_ RLLDT 326_ KLMAS 331_ TQPFK 336_ DIINN 341_ TSLAE 346_ LEKRL 351_ KETPF 356_ NPPKV 361_ ESAEG 366_ FPSYD 371_ TASEQ 376_ LHEAG 381_ YDAYI 386_ TGLCF 391_ ISMAN 396_ YLGSF 401_ LSPPK 406_ IHVSA 411_ RSKLI 416_ EPFFN 421_ KLFLM 426_ RVMDI 431_ PYLNL 436_ EGPDL 441_ QPKRD 446_ HVLHV 451_ TFPKE 456_ WKTSD 461_ LYQLF 466_ SAFGN 471_ IQISW 476_ IDDTS 481_ AFVSL 486_ SQPEQ 491_ VKIAV 496_ NTSKY 501_ AESYR 506_ IQTYA 511_ EYMGR 516_ KQEEK 521_ QIKRK 526_ WTEDS 531_ WKEAD 536_ SKRLN 541_ PQCIP 546_ YTLQN 551_ HYYRN 556_ NSFTA 561_ PSTVG 566_ KRNLS 571_ PSQEE 576_ AGLED 581_ GVSGE 586_ ISDTE 591_ LEQTD 596_ SCAEP 601_ LSEGR 606_ KKAKK 611_ LKRMK 616_ KELSP 621_ AGSIS 626_ KNSPA 631_TLFEV
1: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417)