Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)]
1_MLGIC 6_ RGRRK 11_ FLAAS 16_ LSLLC 21_ IPAIT 26_ WIYLF 31_ SGSFE 36_ DGKPV 41_ SLSPL 46_ ESQAH 51_ SPRYT 56_ ASSQR 61_ ERESL 66_ EVRMR 71_ EVEEE 76_ NRALR 81_ RQLSL 86_ AQGRA 91_ PSHRR 96_ GNHSK 101_ TYSME 106_ EGTGD 111_ SENLR 116_ AGIVA 121_ GNSSE 126_ CGQQP 131_ VVEKC 136_ ETIHV 141_ AIVCA 146_ GYNAS 151_ RDVVT 156_ LVKSV 161_ LFHRR 166_ NPLHF 171_ HLIAD 176_ SIAEQ 181_ ILATL 186_ FQTWM 191_ VPAVR 196_ VDFYN 201_ ADELK 206_ SEVSW 211_ IPNKH 216_ YSGIY 221_ GLMKL 226_ VLTKT 231_ LPANL 236_ ERVIV 241_ LDTDI 246_ TFATD 251_ IAELW 256_ AVFHK 261_ FKGQQ 266_ VLGLV 271_ ENQSD 276_ WYLGN 281_ LWKNH 286_ RPWPA 291_ LGRGY 296_ NTGVI 301_ LLLLD 306_ KLRKM 311_ KWEQM 316_ WRLTA 321_ ERELM 326_ GMLST 331_ SLADQ 336_ DIFNA 341_ VIKQN 346_ PFLVY 351_ QLPCF 356_ WNVQL 361_ SDHTR 366_ SEQCY 371_ RDVSD 376_ LKVIH 381_ WNSPK 386_ KLRVK 391_ NKHVE 396_ FFRNL 401_ YLTFL 406_ EYDGN 411_ LLRRE 416_ LFGCP 421_ SEADV 426_ NSENL 431_ QKQLS 436_ ELDED 441_ DLCYE 446_ FRRER 451_ FTVHR 456_ THLYF 461_ LHYEY 466_ EPAAD 471_ STDVT 476_ LVAQL 481_ SMDRL 486_ QMLEA 491_ ICKHW 496_ EGPIS 501_ LALYL 506_ SDAEA 511_ QQFLR 516_ YAQGS 521_ EVLMS 526_ RHNVG 531_ YHIVY 536_ KEGQF 541_ YPVNL 546_ LRNVA 551_ MKHIS 556_ TPYMF 561_ LSDID 566_ FLPMY 571_ GLYEY 576_ LRKSV 581_ IQLDL 586_ ANTKK 591_ AMIVP 596_ AFETL 601_ RYRLS 606_ FPKSK 611_ AELLS 616_ MLDMG 621_ TLFTF 626_ RYHVW 631_ TKGHA 636_ PTNFA 641_ KWRTA 646_ TTPYR 651_ VEWEA 656_ DFEPY 661_ VVVRR 666_ DCPEY 671_ DRRFV 676_ GFGWN 681_ KVAHI 686_ MELDV 691_ QEYEF 696_ IVLPN 701_ AYMIH 706_ MPHAP 711_ SFDIT 716_ KFRSN 721_ KQYRI 726_ CLKTL 731_ KEEFQ 736_ QDMSR 741_ RYGFA 746_ ALKYL 751_TAENN
1: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity (PubMed:15661757, PubMed:15752776, PubMed:21987822, PubMed:22223806, PubMed:23125099, PubMed:25279697, PubMed:25279699). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:22223806, PubMed:23125099, PubMed:25138275, PubMed:25279697, PubMed:25279699, PubMed:32975514). Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (PubMed:21987822). Plays a key role in skeletal muscle function and regeneration (By similarity)