Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
1_MPSTD 6_ LLMLK 11_ AFEPY 16_ LEILE 21_ VYSTK 26_ AKNYV 31_ NGHCT 36_ KYEPW 41_ QLIAW 46_ SVVWT 51_ LLIVW 56_ GYEFV 61_ FQPES 66_ LWSRF 71_ KKKCF 76_ KLTRK 81_ MPIIG 86_ RKIQD 91_ KLNKT 96_ KDDIS 101_ KNMSF 106_ LKVDK 111_ EYVKA 116_ LPSQG 121_ LSSSA 126_ VLEKL 131_ KEYSS 136_ MDAFW 141_ QEGRA 146_ SGTVY 151_ SGEEK 156_ LTELL 161_ VKAYG 166_ DFAWS 171_ NPLHP 176_ DIFPG 181_ LRKIE 186_ AEIVR 191_ IACSL 196_ FNGGP 201_ DSCGC 206_ VTSGG 211_ TESIL 216_ MACKA 221_ YRDLA 226_ FEKGI 231_ KTPEI 236_ VAPQS 241_ AHAAF 246_ NKAAS 251_ YFGMK 256_ IVRVP 261_ LTKMM 266_ EVDVR 271_ AMRRA 276_ ISRNT 281_ AMLVC 286_ STPQF 291_ PHGVI 296_ DPVPE 301_ VAKLA 306_ VKYKI 311_ PLHVD 316_ ACLGG 321_ FLIVF 326_ MEKAG 331_ YPLEH 336_ PFDFR 341_ VKGVT 346_ SISAD 351_ THKYG 356_ YAPKG 361_ SSLVL 366_ YSDKK 371_ YRNYQ 376_ FFVDT 381_ DWQGG 386_ IYASP 391_ TIAGS 396_ RPGGI 401_ SAACW 406_ AALMH 411_ FGENG 416_ YVEAT 421_ KQIIK 426_ TARFL 431_ KSELE 436_ NIKGI 441_ FVFGN 446_ PQLSV 451_ IALGS 456_ RDFDI 461_ YRLSN 466_ LMTAK 471_ GWNLN 476_ QLQFP 481_ PSIHF 486_ CITLL 491_ HARKR 496_ VAIQF 501_ LKDIR 506_ ESVTQ 511_ IMKNP 516_ KAKTT 521_ GMGAI 526_ YGMAQ 531_ TTVDR 536_ NMVAE 541_ LSSVF 546_ LDSLY 551_ STDTV 556_ TQGSQ 561_MNGSP
1: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity)