CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard)
1_MMRTQ 6_ CLLGL 11_ RTFVA 16_ FAAKL 21_ WSFFI 26_ YLLRR 31_ QIRTV 36_ IQYQT 41_ VRYDI 46_ LPLSP 51_ VSRNR 56_ LAQVK 61_ RKILV 66_ LDLDE 71_ TLIHS 76_ HHDGV 81_ LRPTV 86_ RPGTP 91_ PDFIL 96_ KVVID 101_ KHPVR 106_ FFVHK 111_ RPHVD 116_ FFLEV 121_ VSQWY 126_ ELVVF 131_ TASME 136_ IYGSA 141_ VADKL 146_ DNSRS 151_ ILKRR 156_ YYRQH 161_ CTLEL 166_ GSYIK 171_ DLSVV 176_ HSDLS 181_ SIVIL 186_ DNSPG 191_ AYRSH 196_ PDNAI 201_ PIKSW 206_ FSDPS 211_ DTALL 216_ NLLPM 221_ LDALR 226_ FTADV 231_ RSVLS 236_RNLHQ
1: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling