Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
1_MACWP 6_ QLRLL 11_ LWKNL 16_ TFRRR 21_ QTCQL 26_ LLEVA 31_ WPLFI 36_ FLILI 41_ SVRLS 46_ YPPYE 51_ QHECH 56_ FPNKA 61_ MPSAG 66_ TLPWV 71_ QGIIC 76_ NANNP 81_ CFRYP 86_ TPGEA 91_ PGVVG 96_ NFNKS 101_ IVARL 106_ FSDAR 111_ RLLLY 116_ SQKDT 121_ SMKDM 126_ RKVLR 131_ TLQQI 136_ KKSSS 141_ NLKLQ 146_ DFLVD 151_ NETFS 156_ GFLYH 161_ NLSLP 166_ KSTVD 171_ KMLRA 176_ DVILH 181_ KVFLQ 186_ GYQLH 191_ LTSLC 196_ NGSKS 201_ EEMIQ 206_ LGDQE 211_ VSELC 216_ GLPRE 221_ KLAAA 226_ ERVLR 231_ SNMDI 236_ LKPIL 241_ RTLNS 246_ TSPFP 251_ SKELA 256_ EATKT 261_ LLHSL 266_ GTLAQ 271_ ELFSM 276_ RSWSD 281_ MRQEV 286_ MFLTN 291_ VNSSS 296_ SSTQI 301_ YQAVS 306_ RIVCG 311_ HPEGG 316_ GLKIK 321_ SLNWY 326_ EDNNY 331_ KALFG 336_ GNGTE 341_ EDAET 346_ FYDNS 351_ TTPYC 356_ NDLMK 361_ NLESS 366_ PLSRI 371_ IWKAL 376_ KPLLV 381_ GKILY 386_ TPDTP 391_ ATRQV 396_ MAEVN 401_ KTFQE 406_ LAVFH 411_ DLEGM 416_ WEELS 421_ PKIWT 426_ FMENS 431_ QEMDL 436_ VRMLL 441_ DSRDN 446_ DHFWE 451_ QQLDG 456_ LDWTA 461_ QDIVA 466_ FLAKH 471_ PEDVQ 476_ SSNGS 481_ VYTWR 486_ EAFNE 491_ TNQAI 496_ RTISR 501_ FMECV 506_ NLNKL 511_ EPIAT 516_ EVWLI 521_ NKSME 526_ LLDER 531_ KFWAG 536_ IVFTG 541_ ITPGS 546_ IELPH 551_ HVKYK 556_ IRMDI 561_ DNVER 566_ TNKIK 571_ DGYWD 576_ PGPRA 581_ DPFED 586_ MRYVW 591_ GGFAY 596_ LQDVV 601_ EQAII 606_ RVLTG 611_ TEKKT 616_ GVYMQ 621_ QMPYP 626_ CYVDD 631_ IFLRV 636_ MSRSM 641_ PLFMT 646_ LAWIY 651_ SVAVI 656_ IKGIV 661_ YEKEA 666_ RLKET 671_ MRIMG 676_ LDNSI 681_ LWFSW 686_ FISSL 691_ IPLLV 696_ SAGLL 701_ VVILK 706_ LGNLL 711_ PYSDP 716_ SVVFV 721_ FLSVF 726_ AVVTI 731_ LQCFL 736_ ISTLF 741_ SRANL 746_ AAACG 751_ GIIYF 756_ TLYLP 761_ YVLCV 766_ AWQDY 771_ VGFTL 776_ KIFAS 781_ LLSPV 786_ AFGFG 791_ CEYFA 796_ LFEEQ 801_ GIGVQ 806_ WDNLF 811_ ESPVE 816_ EDGFN 821_ LTTSV 826_ SMMLF 831_ DTFLY 836_ GVMTW 841_ YIEAV 846_ FPGQY 851_ GIPRP 856_ WYFPC 861_ TKSYW 866_ FGEES 871_ DEKSH 876_ PGSNQ 881_ KRISE 886_ ICMEE 891_ EPTHL 896_ KLGVS 901_ IQNLV 906_ KVYRD 911_ GMKVA 916_ VDGLA 921_ LNFYE 926_ GQITS 931_ FLGHN 936_ GAGKT 941_ TTMSI 946_ LTGLF 951_ PPTSG 956_ TAYIL 961_ GKDIR 966_ SEMST 971_ IRQNL 976_ GVCPQ 981_ HNVLF 986_ DMLTV 991_ EEHIW 996_ FYARL 1001_ KGLSE 1006_ KHVKA 1011_ EMEQM 1016_ ALDVG 1021_ LPSSK 1026_ LKSKT 1031_ SQLSG 1036_ GMQRK 1041_ LSVAL 1046_ AFVGG 1051_ SKVVI 1056_ LDEPT 1061_ AGVDP 1066_ YSRRG 1071_ IWELL 1076_ LKYRQ 1081_ GRTII 1086_ LSTHH 1091_ MDEAD 1096_ VLGDR 1101_ IAIIS 1106_ HGKLC 1111_ CVGSS 1116_ LFLKN 1121_ QLGTG 1126_ YYLTL 1131_ VKKDV 1136_ ESSLS 1141_ SCRNS 1146_ SSTVS 1151_ YLKKE 1156_ DSVSQ 1161_ SSSDA 1166_ GLGSD 1171_ HESDT 1176_ LTIDV 1181_ SAISN 1186_ LIRKH 1191_ VSEAR 1196_ LVEDI 1201_ GHELT 1206_ YVLPY 1211_ EAAKE 1216_ GAFVE 1221_ LFHEI 1226_ DDRLS 1231_ DLGIS 1236_ SYGIS 1241_ ETTLE 1246_ EIFLK 1251_ VAEES 1256_ GVDAE 1261_ TSDGT 1266_ LPARR 1271_ NRRAF 1276_ GDKQS 1281_ CLRPF 1286_ TEDDA 1291_ ADPND 1296_ SDIDP 1301_ ESRET 1306_ DLLSG 1311_ MDGKG 1316_ SYQVK 1321_ GWKLT 1326_ QQQFV 1331_ ALLWK 1336_ RLLIA 1341_ RRSRK 1346_ GFFAQ 1351_ IVLPA 1356_ VFVCI 1361_ ALVFS 1366_ LIVPP 1371_ FGKYP 1376_ SLELQ 1381_ PWMYN 1386_ EQYTF 1391_ VSNDA 1396_ PEDTG 1401_ TLELL 1406_ NALTK 1411_ DPGFG 1416_ TRCME 1421_ GNPIP 1426_ DTPCQ 1431_ AGEEE 1436_ WTTAP 1441_ VPQTI 1446_ MDLFQ 1451_ NGNWT 1456_ MQNPS 1461_ PACQC 1466_ SSDKI 1471_ KKMLP 1476_ VCPPG 1481_ AGGLP 1486_ PPQRK 1491_ QNTAD 1496_ ILQDL 1501_ TGRNI 1506_ SDYLV 1511_ KTYVQ 1516_ IIAKS 1521_ LKNKI 1526_ WVNEF 1531_ RYGGF 1536_ SLGVS 1541_ NTQAL 1546_ PPSQE 1551_ VNDAI 1556_ KQMKK 1561_ HLKLA 1566_ KDSSA 1571_ DRFLN 1576_ SLGRF 1581_ MTGLD 1586_ TKNNV 1591_ KVWFN 1596_ NKGWH 1601_ AISSF 1606_ LNVIN 1611_ NAILR 1616_ ANLQK 1621_ GENPS 1626_ HYGIT 1631_ AFNHP 1636_ LNLTK 1641_ QQLSE 1646_ VALMT 1651_ TSVDV 1656_ LVSIC 1661_ VIFAM 1666_ SFVPA 1671_ SFVVF 1676_ LIQER 1681_ VSKAK 1686_ HLQFI 1691_ SGVKP 1696_ VIYWL 1701_ SNFVW 1706_ DMCNY 1711_ VVPAT 1716_ LVIII 1721_ FICFQ 1726_ QKSYV 1731_ SSTNL 1736_ PVLAL 1741_ LLLLY 1746_ GWSIT 1751_ PLMYP 1756_ ASFVF 1761_ KIPST 1766_ AYVVL 1771_ TSVNL 1776_ FIGIN 1781_ GSVAT 1786_ FVLEL 1791_ FTDNK 1796_ LNNIN 1801_ DILKS 1806_ VFLIF 1811_ PHFCL 1816_ GRGLI 1821_ DMVKN 1826_ QAMAD 1831_ ALERF 1836_ GENRF 1841_ VSPLS 1846_ WDLVG 1851_ RNLFA 1856_ MAVEG 1861_ VVFFL 1866_ ITVLI 1871_ QYRFF 1876_ IRPRP 1881_ VNAKL 1886_ SPLND 1891_ EDEDV 1896_ RRERQ 1901_ RILDG 1906_ GGQND 1911_ ILEIK 1916_ ELTKI 1921_ YRRKR 1926_ KPAVD 1931_ RICVG 1936_ IPPGE 1941_ CFGLL 1946_ GVNGA 1951_ GKSST 1956_ FKMLT 1961_ GDTTV 1966_ TRGDA 1971_ FLNKN 1976_ SILSN 1981_ IHEVH 1986_ QNMGY 1991_ CPQFD 1996_ AITEL 2001_ LTGRE 2006_ HVEFF 2011_ ALLRG 2016_ VPEKE 2021_ VGKVG 2026_ EWAIR 2031_ KLGLV 2036_ KYGEK 2041_ YAGNY 2046_ SGGNK 2051_ RKLST 2056_ AMALI 2061_ GGPPV 2066_ VFLDE 2071_ PTTGM 2076_ DPKAR 2081_ RFLWN 2086_ CALSV 2091_ VKEGR 2096_ SVVLT 2101_ SHSME 2106_ ECEAL 2111_ CTRMA 2116_ IMVNG 2121_ RFRCL 2126_ GSVQH 2131_ LKNRF 2136_ GDGYT 2141_ IVVRI 2146_ AGSNP 2151_ DLKPV 2156_ QDFFG 2161_ LAFPG 2166_ SVLKE 2171_ KHRNM 2176_ LQYQL 2181_ PSSLS 2186_ SLARI 2191_ FSILS 2196_ QSKKR 2201_ LHIED 2206_ YSVSQ 2211_ TTLDQ 2216_ VFVNF 2221_ AKDQS 2226_ DDDHL 2231_ KDLSL 2236_ HKNQT 2241_ VVDVA 2246_ VLTSF 2251_ LQDEK 2256_VKESY
1: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019)