GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]
1_MWNML 6_ IVAMC 11_ LALLG 16_ CLQAQ 21_ ELQGH 26_ VSIIL 31_ LGATG 36_ DLAKK 41_ YLWQG 46_ LFQLY 51_ LDEAG 56_ RGHSF 61_ SFHGA 66_ ALTAP 71_ KQGQE 76_ LMAKA 81_ LESLS 86_ CPKDM 91_ APSHC 96_ AEHKD 101_ QFLQL 106_ SQYRQ 111_ LKTAE 116_ DYQAL 121_ NKDIE 126_ AQLQH 131_ AGLRE 136_ AGRIF 141_ YFSVP 146_ PFAYE 151_ DIARN 156_ INSSC 161_ RPGPG 166_ AWLRV 171_ VLEKP 176_ FGHDH 181_ FSAQQ 186_ LATEL 191_ GTFFQ 196_ EEEMY 201_ RVDHY 206_ LGKQA 211_ VAQIL 216_ PFRDQ 221_ NRKAL 226_ DGLWN 231_ RHHVE 236_ RVEII 241_ MKETV 246_ DAEGR 251_ TSFYE 256_ EYGVI 261_ RDVLQ 266_ NHLTE 271_ VLTLV 276_ AMELP 281_ HNVSS 286_ AEAVL 291_ RHKLQ 296_ VFQAL 301_ RGLQR 306_ GSAVV 311_ GQYQS 316_ YSEQV 321_ RRELQ 326_ KPDSF 331_ HSLTP 336_ TFAAV 341_ LVHID 346_ NLRWE 351_ GVPFI 356_ LMSGK 361_ ALDER 366_ VGYAR 371_ ILFKN 376_ QACCV 381_ QSEKH 386_ WAAAQ 391_ SQCLP 396_ RQLVF 401_ HIGHG 406_ DLGSP 411_ AVLVS 416_ RNLFR 421_ PSLPS 426_ SWKEM 431_ EGPPG 436_ LRLFG 441_ SPLSD 446_ YYAYS 451_ PVRER 456_ DAHSV 461_ LLSHI 466_ FHGRK 471_ NFFIT 476_ TENLL 481_ ASWNF 486_ WTPLL 491_ ESLAH 496_ KAPRL 501_ YPGGA 506_ ENGRL 511_ LDFEF 516_ SSGRL 521_ FFSQQ 526_ QPEQL 531_ VPGPG 536_ PAPMP 541_ SDFQV 546_ LRAKY 551_ RESPL 556_ VSAWS 561_ EELIS 566_ KLAND 571_ IEATA 576_ VRAVR 581_ RFGQF 586_ HLALS 591_ GGSSP 596_ VALFQ 601_ QLATA 606_ HYGFP 611_ WAHTH 616_ LWLVD 621_ ERCVP 626_ LSDPE 631_ SNFQG 636_ LQAHL 641_ LQHVR 646_ IPYYN 651_ IHPMP 656_ VHLQQ 661_ RLCAE 666_ EDQGA 671_ QIYAR 676_ EISAL 681_ VANSS 686_ FDLVL 691_ LGMGA 696_ DGHTA 701_ SLFPQ 706_ SPTGL 711_ DGEQL 716_ VVLTT 721_ SPSQP 726_ HRRMS 731_ LSLPL 736_ INRAK 741_ KVAVL 746_ VMGRM 751_ KREIT 756_ TLVSR 761_ VGHEP 766_ KKWPI 771_ SGVLP 776_ HSGQL 781_ VWYMD 786_YDAFL
1: Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520)