Chromobox protein homolog 6
1_MELSA 6_ VGERV 11_ FAAES 16_ IIKRR 21_ IRKGR 26_ IEYLV 31_ KWKGW 36_ AIKYS 41_ TWEPE 46_ ENILD 51_ SRLIA 56_ AFEQK 61_ ERERE 66_ LYGPK 71_ KRGPK 76_ PKTFL 81_ LKARA 86_ QAEAL 91_ RISDV 96_ HFSVK 101_ PSASA 106_ SSPKL 111_ HSSAA 116_ VHRLK 121_ KDIRR 126_ CHRMS 131_ RRPLP 136_ RPDPQ 141_ GGSPG 146_ LRPPI 151_ SPFSE 156_ TVRII 161_ NRKVK 166_ PREPK 171_ RNRII 176_ LNLKV 181_ IDKGA 186_ GGGGA 191_ GQGAG 196_ ALARP 201_ KVPSR 206_ NRVIG 211_ KSKKF 216_ SESVL 221_ RTQIR 226_ HMKFG 231_ AFALY 236_ KPPPA 241_ PLVAP 246_ SPGKA 251_ EASAP 256_ GPGLL 261_ LAAPA 266_ APYDA 271_ RSSGS 276_ SGCPS 281_ PTPQS 286_ SDPDD 291_ TPPKL 296_ LPETV 301_ SPSAP 306_ SWREP 311_ EVLDL 316_ SLPPE 321_ SAATS 326_ KRAPP 331_ EVTAA 336_ AGPAP 341_ PTAPE 346_ PAGAS 351_ SEPEA 356_ GDWRP 361_ EMSPC 366_ SNVVV 371_ TDVTS 376_ NLLTV 381_ TIKEF 386_ CNPED 391_ FEKVA 396_ AGVAG 401_ AAGGG 406_GSIGA
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity)