Histidine protein methyltransferase 1 homolog (EC 2.1.1.85) (Arsenic-transactivated protein 2) (AsTP2) (Methyltransferase-like protein 18)
1_MTFQF 6_ NFTIE 11_ DHLEN 16_ ELTPI 21_ RDGAL 26_ TLDSS 31_ KELSV 36_ SESQK 41_ GEERD 46_ RKCSA 51_ EQFDL 56_ PQDHL 61_ WEHKS 66_ MENAA 71_ PSQDT 76_ DSPLS 81_ AASSS 86_ RNLEP 91_ HGKQP 96_ SLRAA 101_ KEHAM 106_ PKDLK 111_ KMLEN 116_ KVIET 121_ LPGFQ 126_ HVKLS 131_ VVKTI 136_ LLKEN 141_ FPGEN 146_ IVSKS 151_ FSSHS 156_ DLITG 161_ VYEGG 166_ LKIWE 171_ CTFDL 176_ LAYFT 181_ KAKVK 186_ FAGKK 191_ VLDLG 196_ CGSGL 201_ LGITA 206_ FKGGS 211_ KEIHF 216_ QDYNS 221_ MVIDE 226_ VTLPN 231_ VVANS 236_ TLEDE 241_ ENDVN 246_ EPDVK 251_ RCRKP 256_ KVTQL 261_ YKCRF 266_ FSGEW 271_ SEFCK 276_ LVLSS 281_ EKLFV 286_ KYDLI 291_ LTSET 296_ IYNPD 301_ YYSNL 306_ HQTFL 311_ RLLSK 316_ NGRVL 321_ LASKA 326_ HYFGV 331_ GGGVH 336_ LFQKF 341_ VEERD 346_ VFKTR 351_ ILKII 356_ DEGLK 361_ RFIIE 366_ITFKF
1: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491). Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491)